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Theranostic applications of phage display to control leishmaniasis: selection of biomarkers for serodiagnostics, vaccination, and immunotherapy

Overview of attention for article published in Revista da Sociedade Brasileira de Medicina Tropical, August 2015
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Title
Theranostic applications of phage display to control leishmaniasis: selection of biomarkers for serodiagnostics, vaccination, and immunotherapy
Published in
Revista da Sociedade Brasileira de Medicina Tropical, August 2015
DOI 10.1590/0037-8682-0096-2015
Pubmed ID
Authors

Eduardo Antonio Ferraz Coelho, Miguel Angel Chávez-Fumagalli, Lourena Emanuele Costa, Carlos Alberto Pereira Tavares, Manuel Soto, Luiz Ricardo Goulart

Abstract

Phage display is a high-throughput subtractive proteomic technology used for the generation and screening of large peptide and antibody libraries. It is based on the selection of phage-fused surface-exposed peptides that recognize specific ligands and demonstrate desired functionality for diagnostic and therapeutic purposes. Phage display has provided unmatched tools for controlling viral, bacterial, fungal, and parasitic infections, and allowed identification of new therapeutic targets to treat cancer, metabolic diseases, and other chronic conditions. This review presents recent advancements in serodiagnostics and prevention of leishmaniasis -an important tropical parasitic disease- achieved using phage display for the identification of novel antigens with improved sensitivity and specificity. Our focus is on theranostics of visceral leishmaniasis with the aim to develop biomarker candidates exhibiting both diagnostic and therapeutic potential to fight this important, yet neglected, tropical disease.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 69 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Malaysia 1 1%
Brazil 1 1%
Unknown 67 97%

Demographic breakdown

Readers by professional status Count As %
Student > Master 13 19%
Student > Ph. D. Student 12 17%
Researcher 9 13%
Student > Bachelor 7 10%
Other 3 4%
Other 6 9%
Unknown 19 28%
Readers by discipline Count As %
Agricultural and Biological Sciences 11 16%
Medicine and Dentistry 8 12%
Biochemistry, Genetics and Molecular Biology 7 10%
Veterinary Science and Veterinary Medicine 5 7%
Nursing and Health Professions 3 4%
Other 12 17%
Unknown 23 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 October 2018.
All research outputs
#19,944,091
of 25,373,627 outputs
Outputs from Revista da Sociedade Brasileira de Medicina Tropical
#669
of 1,193 outputs
Outputs of similar age
#188,876
of 276,419 outputs
Outputs of similar age from Revista da Sociedade Brasileira de Medicina Tropical
#10
of 18 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,193 research outputs from this source. They receive a mean Attention Score of 2.9. This one is in the 38th percentile – i.e., 38% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 276,419 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.