Title |
Reactivation of Chagas disease after autologous hematopoietic stem cell transplantation
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Published in |
Revista da Sociedade Brasileira de Medicina Tropical, January 2021
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DOI | 10.1590/0037-8682-0143-2020 |
Pubmed ID | |
Authors |
Claudia Marcela Chalela, Angela Maria Peña, Angela Maria Roa, David L. Reyes, Jennifer Paola Rueda, Luis Antonio Salazar, Manuel Rosales, Edgar David Gomez, Edgar Augusto Bernal, Claudia Lucia Sossa Melo |
Abstract |
Chagas disease (CD) is a protozoan zoonosis caused by Trypanosoma cruzi. Reactivation of CD occurs via drug-induced immunosuppression before and during transplantation. Here, we report the case of a 62-year-old man diagnosed with classic Hodgkin lymphoma who received highly aggressive conditioning chemotherapy before undergoing stem cell transplantation (SCT). The patient tested positive for CD in pre-transplantation evaluation. The patient exhibited persistent fever and elevated C-reactive protein levels before and after SCT, and was treated with antibiotics. Micro-Strout test showed evidence of trypomastigotes and he was treated with benznidazole until tested negative. Post-transplantation seropositive patients should be screened for possible reactivation. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 20 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Other | 2 | 10% |
Student > Ph. D. Student | 2 | 10% |
Student > Postgraduate | 2 | 10% |
Researcher | 2 | 10% |
Professor | 1 | 5% |
Other | 1 | 5% |
Unknown | 10 | 50% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 5 | 25% |
Agricultural and Biological Sciences | 1 | 5% |
Nursing and Health Professions | 1 | 5% |
Social Sciences | 1 | 5% |
Immunology and Microbiology | 1 | 5% |
Other | 0 | 0% |
Unknown | 11 | 55% |