Title |
Selective activity of diselenides against Aedes aegypti (Diptera: Culicidae) larvae
|
---|---|
Published in |
Revista da Sociedade Brasileira de Medicina Tropical, January 2021
|
DOI | 10.1590/0037-8682-0146-2020 |
Pubmed ID | |
Authors |
Sabrina Ketrin Targanski, Janaina Rosa Sousa, André Luiz Agnes Stein, Marcos Antônio Soares |
Abstract |
Aedes aegypti (L.) is the major vector of arboviruses that causes serious public health concerns in tropical and subtropical countries. We examined the larvicidal activity of 1,2-diphenyldiselenide [(PhSe)2] and 1,2-bis(4-chlorophenyl) diselenide [(p-ClPhSe)2] and determine its toxicity to different non-target organisms. (PhSe)2 and (p-ClPhSe)2 killed Ae. aegypti L3 larvae with LC50/24h values of 65.63 µM (20.48 mg/L) and 355.19 µM (135.33 mg/L), respectively. (PhSe)2 was not toxic to the four model organisms. (PhSe)2 is a larvicidal compound with selective action against Ae. aegypti larvae. The mechanisms of action of (PhSe)2 under field conditions remain to be investigated. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 14 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 3 | 21% |
Student > Bachelor | 2 | 14% |
Unspecified | 1 | 7% |
Other | 1 | 7% |
Student > Doctoral Student | 1 | 7% |
Other | 1 | 7% |
Unknown | 5 | 36% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 2 | 14% |
Medicine and Dentistry | 2 | 14% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 7% |
Unspecified | 1 | 7% |
Environmental Science | 1 | 7% |
Other | 1 | 7% |
Unknown | 6 | 43% |