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Efficacy and tolerability of two single-day regimens of triclabendazole for fascioliasis in Peruvian children

Overview of attention for article published in Revista da Sociedade Brasileira de Medicina Tropical, August 2015
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Title
Efficacy and tolerability of two single-day regimens of triclabendazole for fascioliasis in Peruvian children
Published in
Revista da Sociedade Brasileira de Medicina Tropical, August 2015
DOI 10.1590/0037-8682-0148-2015
Pubmed ID
Authors

Vicente Maco, Luis Marcos, Jaime Delgado, Julio Herrera, José Nestares, Angelica Terashima, Frine Samalvides, Eduardo Gotuzzo

Abstract

The therapeutic scheme of triclabendazole (TCBZ), the recommended anthelmintic against Fasciola hepatica , involves 10mg/kg of body weight administered in a single dose; however, clinical trials in children are scarce. We evaluated the efficacy and tolerability of 2 schemes of TCBZ. Eighty-four Peruvian children with F. hepatica eggs in their stools were allocated into 2 groups: 44 received 2 dosages of 7.5mg/kg each with a 12-h interval (Group I), and 40 received a single 10-mg/kg dose (Group II). Evaluation of efficacy was based on the presence of eggs in stools, and tolerability was based on the presence of symptoms and signs post-treatment. A parasitological cure was obtained in 100% of individuals from Group I and 95% of individuals from Group II. The most common adverse event was biliary colic. The tested scheme was efficacious and tolerable, and it might be an optimal scheme in the region. To the best of our knowledge, this represents the largest series of children treated with TCBZ in a non-hospital setting.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 30 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 23%
Professor > Associate Professor 3 10%
Student > Bachelor 3 10%
Librarian 2 7%
Professor 2 7%
Other 7 23%
Unknown 6 20%
Readers by discipline Count As %
Medicine and Dentistry 8 27%
Veterinary Science and Veterinary Medicine 4 13%
Agricultural and Biological Sciences 3 10%
Immunology and Microbiology 3 10%
Environmental Science 1 3%
Other 5 17%
Unknown 6 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 January 2016.
All research outputs
#19,944,091
of 25,373,627 outputs
Outputs from Revista da Sociedade Brasileira de Medicina Tropical
#669
of 1,193 outputs
Outputs of similar age
#188,876
of 276,419 outputs
Outputs of similar age from Revista da Sociedade Brasileira de Medicina Tropical
#10
of 18 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,193 research outputs from this source. They receive a mean Attention Score of 2.9. This one is in the 38th percentile – i.e., 38% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 276,419 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.