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Invasive fungal infection in patients with hematologic disorders in a Brazilian tertiary care hospital

Overview of attention for article published in Revista da Sociedade Brasileira de Medicina Tropical, February 2017
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Title
Invasive fungal infection in patients with hematologic disorders in a Brazilian tertiary care hospital
Published in
Revista da Sociedade Brasileira de Medicina Tropical, February 2017
DOI 10.1590/0037-8682-0191-2016
Pubmed ID
Authors

Milton Camplesi, Hildene Meneses Silva, Adriano Moraes Arantes, Carolina Rodrigues Costa, Fábio Silvestre Ataides, Thaisa Cristina Silva, Maysa de Paula Costa dos Reis, Maria do Rosário Rodrigues Silva

Abstract

Invasive fungal infections (IFIs) are an important complication in immunocompromised individuals, particularly neutropenic patients with hematological malignancies. In this study, we aimed to verify the epidemiology and diagnosis of IFIs in patients with hematologic problems at a tertiary hospital in Goiânia-GO, Brazil. Data from 117 patients, involving 19 cases of IFIs, were collected. The collected data included diagnosis methods, demographics, clinical characteristics, and in vitro susceptibility to different antifungal agents. Among the 19 cases, 12 were classified as proven IFI and 7 as probable invasive aspergillosis with detection of galactomannan in blood and presence of lung infiltrates in radiographic images. Logistic regression analysis showed that the proven and probable IFIs were associated with increased risk of death. Statistical analysis demonstrated that age, sex, and underlying disease were not independently associated with risk of death in IFI patients. Most bloodstream isolates of Candida spp. exhibited low minimum inhibitory concentrations (MICs) to all antifungal agents tested. Voriconazole and amphotericin had the lowest MICs for Aspergillus spp. and Fusarium spp., but Fusarium spp. showed the least susceptibility to all antifungals tested. Amphotericin B, fluconazole, and itraconazole were found to be inactive in vitro against Acremonium kiliense; but this fungus was sensitive to voriconazole. Considering the high number of IFI cases, with crude mortality rate of 6%, we could conclude that IFIs remain a common infection in patients with hematological malignancies and underdiagnosed ante mortem. Thus, IFIs should be monitored closely.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 55 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Colombia 1 2%
Unknown 54 98%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 9 16%
Student > Master 8 15%
Researcher 5 9%
Other 4 7%
Student > Ph. D. Student 3 5%
Other 9 16%
Unknown 17 31%
Readers by discipline Count As %
Medicine and Dentistry 10 18%
Immunology and Microbiology 5 9%
Pharmacology, Toxicology and Pharmaceutical Science 4 7%
Veterinary Science and Veterinary Medicine 2 4%
Agricultural and Biological Sciences 2 4%
Other 9 16%
Unknown 23 42%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 May 2017.
All research outputs
#19,951,180
of 25,382,440 outputs
Outputs from Revista da Sociedade Brasileira de Medicina Tropical
#669
of 1,193 outputs
Outputs of similar age
#307,054
of 424,972 outputs
Outputs of similar age from Revista da Sociedade Brasileira de Medicina Tropical
#12
of 24 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,193 research outputs from this source. They receive a mean Attention Score of 2.9. This one is in the 38th percentile – i.e., 38% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 424,972 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 24th percentile – i.e., 24% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.