Title |
Production of metallo-β-lactamase among Pseudomonas aeruginosa strains isolated in the State of Sergipe, Brazil
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Published in |
Revista da Sociedade Brasileira de Medicina Tropical, April 2015
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DOI | 10.1590/0037-8682-0198-2014 |
Pubmed ID | |
Authors |
Lívia Maria do Amorim Costa, Maria Emília de Castro Kling Fleming, Geraldo Renato de Paula, Lenise Arneiro Teixeira, Pedro Juan José Mondino, Sílvia Susana Bona de Mondino, Cláudia Rezende de Vieira Mendonça-Souza |
Abstract |
Acquired production of metallo-β-lactamases is an important mechanism of resistance in Pseudomonas aeruginosa. The objective of this study was to investigate the production of metallo-β-lactamase and the genetic diversity among ceftazidime-resistant P. aeruginosa isolates from State of Sergipe, Brazil. Metallo-β-lactamase was investigated using the disk approximation test and polymerase chain reaction (PCR). Genetic diversity was evaluated by pulsed-field gel electrophoresis (PFGE). A total of 48 (51.6%) isolates were resistant to ceftazidime. Six (12.2%) of these were positive for metallo-β-lactamase production. Only two (4.1%) of the ceftazidime-resistant isolates carried the bla SPM-1 gene. Production of metallo-β-lactamases was not the main mechanism of resistance to ceftazidime and carbapenems among P. aeruginosa strains in Sergipe, Brazil. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Colombia | 1 | 25% |
United Kingdom | 1 | 25% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 6% |
Unknown | 17 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 6 | 33% |
Student > Bachelor | 3 | 17% |
Student > Doctoral Student | 2 | 11% |
Professor | 1 | 6% |
Other | 1 | 6% |
Other | 2 | 11% |
Unknown | 3 | 17% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 6 | 33% |
Biochemistry, Genetics and Molecular Biology | 4 | 22% |
Medicine and Dentistry | 2 | 11% |
Immunology and Microbiology | 1 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 6% |
Other | 0 | 0% |
Unknown | 4 | 22% |