Title |
Puerperal brain cryptococcoma in an HIV-negative woman successfully treated with fluconazole: a case report
|
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Published in |
Revista da Sociedade Brasileira de Medicina Tropical, April 2014
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DOI | 10.1590/0037-8682-0215-2013 |
Pubmed ID | |
Authors |
José Edward Hagan, Jesângeli Sousa Dias, José Caetano Villasboas-Bisneto, Melissa Barreto Falcão, Albert Icksang Ko, Guilherme Sousa Ribeiro |
Abstract |
Cryptococcus spp. cerebral abscesses are uncommon in immunocompetent subjects. The recommended induction treatment is the administration of amphotericin B plus flucytosine combined with resection for lesions ≥3cm. In this paper, we describe an HIV-negative woman diagnosed with a large cryptococcoma in the immediate postpartum period. The lesion was not resected, and due to amphotericin B intolerance, she received an extended course of fluconazole monotherapy. There was no disease recurrence during the 4 years of follow-up. The abrupt onset of her symptoms following delivery suggests that she developed a postpartum immune reconstitution syndrome. This case also demonstrates that in specific situations fluconazole monotherapy can be attempted in immunocompetent patients with cryptococcoma. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | 3% |
Netherlands | 1 | 3% |
Unknown | 34 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 6 | 17% |
Student > Bachelor | 4 | 11% |
Student > Postgraduate | 4 | 11% |
Other | 3 | 8% |
Student > Ph. D. Student | 3 | 8% |
Other | 5 | 14% |
Unknown | 11 | 31% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 21 | 58% |
Immunology and Microbiology | 1 | 3% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
Unknown | 13 | 36% |