Title |
An overview of malaria transmission from the perspective of Amazon Anopheles vectors
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Published in |
Memórias do Instituto Oswaldo Cruz, February 2015
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DOI | 10.1590/0074-02760140266 |
Pubmed ID | |
Authors |
Paulo FP Pimenta, Alessandra S Orfano, Ana C Bahia, Ana PM Duarte, Claudia M Ríos-Velásquez, Fabrício F Melo, Felipe AC Pessoa, Giselle A Oliveira, Keillen MM Campos, Luis Martínez Villegas, Nilton Barnabé Rodrigues, Rafael Nacif-Pimenta, Rejane C Simões, Wuelton M Monteiro, Rogerio Amino, Yara M Traub-Cseko, José BP Lima, Maria GV Barbosa, Marcus VG Lacerda, Wanderli P Tadei, Nágila FC Secundino |
Abstract |
In the Americas, areas with a high risk of malaria transmission are mainly located in the Amazon Forest, which extends across nine countries. One keystone step to understanding the Plasmodium life cycle in Anopheles species from the Amazon Region is to obtain experimentally infected mosquito vectors. Several attempts to colonise Ano- pheles species have been conducted, but with only short-lived success or no success at all. In this review, we review the literature on malaria transmission from the perspective of its Amazon vectors. Currently, it is possible to develop experimental Plasmodium vivax infection of the colonised and field-captured vectors in laboratories located close to Amazonian endemic areas. We are also reviewing studies related to the immune response to P. vivax infection of Anopheles aquasalis, a coastal mosquito species. Finally, we discuss the importance of the modulation of Plasmodium infection by the vector microbiota and also consider the anopheline genomes. The establishment of experimental mosquito infections with Plasmodium falciparum, Plasmodium yoelii and Plasmodium berghei parasites that could provide interesting models for studying malaria in the Amazonian scenario is important. Understanding the molecular mechanisms involved in the development of the parasites in New World vectors is crucial in order to better determine the interaction process and vectorial competence. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Czechia | 2 | <1% |
Brazil | 2 | <1% |
Madagascar | 2 | <1% |
United Kingdom | 1 | <1% |
Unknown | 428 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 70 | 16% |
Student > Bachelor | 69 | 16% |
Student > Ph. D. Student | 47 | 11% |
Researcher | 41 | 9% |
Student > Doctoral Student | 22 | 5% |
Other | 58 | 13% |
Unknown | 128 | 29% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 90 | 21% |
Biochemistry, Genetics and Molecular Biology | 66 | 15% |
Medicine and Dentistry | 45 | 10% |
Immunology and Microbiology | 31 | 7% |
Nursing and Health Professions | 14 | 3% |
Other | 56 | 13% |
Unknown | 133 | 31% |