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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The efficacy of 2-nitrovinylfuran derivatives againstLeishmania in vitro and in vivo
|
|---|---|
| Published in |
Memórias do Instituto Oswaldo Cruz, April 2015
|
| DOI | 10.1590/0074-02760140324 |
| Pubmed ID | |
| Authors |
Sergio Sifontes-Rodríguez, Lianet Monzote-Fidalgo, Nilo Castañedo-Cancio, Ana Margarita Montalvo-Álvarez, Yamilé López-Hernández, Niurka Mollineda Diogo, Juan Francisco Infante-Bourzac, Oliver Pérez-Martín, Alfredo Meneses-Marcel, José Antonio Escario García-Trevijano, Miguel Ángel Cabrera-Pérez |
| Abstract |
Despite recent advances in the treatment of some forms of leishmaniasis, the available drugs are still far from ideal due to inefficacy, parasite resistance, toxicity and cost. The wide-spectrum antimicrobial activity of 2-nitrovinylfuran compounds has been described, as has their activity against Trichomonas vaginalis and other protozoa. Thus, the aim of this study was to test the antileishmanial activities of six 2-nitrovinylfurans in vitro and in a murine model of leishmaniasis. Minimum parasiticide concentration (MPC) and 50% inhibitory concentration (IC50) values for these compounds against the promastigotes of Leishmania amazonensis, Leishmania infantum and Leishmania braziliensis were determined, as were the efficacies of two selected compounds in an experimental model of cutaneous leishmaniasis (CL) caused by L. amazonensis in BALB/c mice. All of the compounds were active against the promastigotes of the three Leishmania species tested. IC50 and MPC values were in the ranges of 0.8-4.7 µM and 1.7-32 µM, respectively. The compounds 2-bromo-5-(2-bromo-2-nitrovinyl)-furan (furvina) and 2-bromo-5-(2-methyl-2-nitrovinyl)-furan (UC245) also reduced lesion growth in vivo at a magnitude comparable to or higher than that achieved by amphotericin B treatment. The results demonstrate the potential of this class of compounds as antileishmanial agents and support the clinical testing of Dermofural(r) (a furvina-containing antifungal ointment) for the treatment of CL. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 78 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 1% |
| Brazil | 1 | 1% |
| Unknown | 76 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 12 | 15% |
| Student > Bachelor | 12 | 15% |
| Student > Master | 12 | 15% |
| Student > Doctoral Student | 5 | 6% |
| Student > Ph. D. Student | 5 | 6% |
| Other | 13 | 17% |
| Unknown | 19 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 13 | 17% |
| Pharmacology, Toxicology and Pharmaceutical Science | 10 | 13% |
| Medicine and Dentistry | 9 | 12% |
| Biochemistry, Genetics and Molecular Biology | 8 | 10% |
| Chemistry | 5 | 6% |
| Other | 11 | 14% |
| Unknown | 22 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 May 2015.
All research outputs
#17,751,741
of 22,796,179 outputs
Outputs from Memórias do Instituto Oswaldo Cruz
#1,015
of 1,377 outputs
Outputs of similar age
#180,943
of 264,677 outputs
Outputs of similar age from Memórias do Instituto Oswaldo Cruz
#17
of 27 outputs
Altmetric has tracked 22,796,179 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,377 research outputs from this source. They receive a mean Attention Score of 4.4. This one is in the 22nd percentile – i.e., 22% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,677 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 27 others from the same source and published within six weeks on either side of this one. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.