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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Biomarkers of therapeutic responses in chronic Chagas disease: state of the art and future perspectives
|
|---|---|
| Published in |
Memórias do Instituto Oswaldo Cruz, April 2015
|
| DOI | 10.1590/0074-02760140435 |
| Pubmed ID | |
| Authors |
Maria-Jesus Pinazo, Maria-Carmen Thomas, Juan Bustamante, Igor Correia de Almeida, Manuel-Carlos Lopez, Joaquim Gascon |
| Abstract |
The definition of a biomarker provided by the World Health Organization is any substance, structure, or process that can be measured in the body, or its products and influence, or predict the incidence or outcome of disease. Currently, the lack of prognosis and progression markers for chronic Chagas disease has posed limitations for testing new drugs to treat this neglected disease. Several molecules and techniques to detect biomarkers in Trypanosoma cruzi-infected patients have been proposed to assess whether specific treatment with benznidazole or nifurtimox is effective. Isolated proteins or protein groups from different T. cruzi stages and parasite-derived glycoproteins and synthetic neoglycoconjugates have been demonstrated to be useful for this purpose, as have nucleic acid amplification techniques. The amplification of T. cruzi DNA using the real-time polymerase chain reaction method is the leading test for assessing responses to treatment in a short period of time. Biochemical biomarkers have been tested early after specific treatment. Cytokines and surface markers represent promising molecules for the characterisation of host cellular responses, but need to be further assessed. |
X Demographics
The data shown below were collected from the profiles of 12 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Argentina | 5 | 42% |
| Brazil | 1 | 8% |
| Unknown | 6 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 12 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 129 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | <1% |
| Unknown | 128 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 21 | 16% |
| Student > Ph. D. Student | 16 | 12% |
| Student > Master | 16 | 12% |
| Student > Doctoral Student | 14 | 11% |
| Student > Bachelor | 11 | 9% |
| Other | 21 | 16% |
| Unknown | 30 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 23 | 18% |
| Medicine and Dentistry | 21 | 16% |
| Immunology and Microbiology | 15 | 12% |
| Biochemistry, Genetics and Molecular Biology | 13 | 10% |
| Chemistry | 8 | 6% |
| Other | 15 | 12% |
| Unknown | 34 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 January 2020.
All research outputs
#3,343,077
of 25,374,647 outputs
Outputs from Memórias do Instituto Oswaldo Cruz
#77
of 1,502 outputs
Outputs of similar age
#41,523
of 279,305 outputs
Outputs of similar age from Memórias do Instituto Oswaldo Cruz
#3
of 33 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,502 research outputs from this source. They receive a mean Attention Score of 4.6. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 279,305 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 33 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.