Title |
Pharmacokinetic and pharmacodynamic responses in adult patients with Chagas disease treated with a new formulation of benznidazole
|
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Published in |
Memórias do Instituto Oswaldo Cruz, March 2016
|
DOI | 10.1590/0074-02760150401 |
Pubmed ID | |
Authors |
Marisa Liliana Fernández, Maria Elena Marson, Juan Carlos Ramirez, Guido Mastrantonio, Alejandro Gabriel Schijman, Jaime Altcheh, Adelina Rosa Riarte, Facundo García Bournissen |
Abstract |
Pharmacological treatment of Chagas disease with benznidazole (BNZ) is effective in children in all stages, but it is controversial in chronically infected adults. We report the pharmacokinetics and pharmacodynamics in six adult patients with Chagas disease treated with the new BNZ formulation (ABARAX®) in doses between 2.5-5.5 mg/Kg/day. All but one patient had plasmatic BNZ concentrations within the expected range. All patients finalised treatment with nondetectable Trypanosoma cruzi quantitative polymerase chain reaction, which remained nondetectable at the six month follow-up. Our data suggests parasitological responses with the new BNZ and supports the hypothesis that treatment protocols with lower BNZ doses may be effective. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Argentina | 2 | 29% |
Unknown | 5 | 71% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 7 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Brazil | 2 | 3% |
Colombia | 1 | 1% |
Unknown | 68 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 12 | 17% |
Researcher | 9 | 13% |
Student > Ph. D. Student | 8 | 11% |
Student > Doctoral Student | 7 | 10% |
Other | 6 | 8% |
Other | 10 | 14% |
Unknown | 19 | 27% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 11 | 15% |
Agricultural and Biological Sciences | 10 | 14% |
Pharmacology, Toxicology and Pharmaceutical Science | 8 | 11% |
Biochemistry, Genetics and Molecular Biology | 7 | 10% |
Chemistry | 6 | 8% |
Other | 5 | 7% |
Unknown | 24 | 34% |