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Experimental toxocariasis in BALB/c mice: relationship between parasite inoculum and the IgG immune response

Overview of attention for article published in Memórias do Instituto Oswaldo Cruz, March 2017
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Title
Experimental toxocariasis in BALB/c mice: relationship between parasite inoculum and the IgG immune response
Published in
Memórias do Instituto Oswaldo Cruz, March 2017
DOI 10.1590/0074-02760160341
Pubmed ID
Authors

Gabriela Rodrigues e Fonseca, Sergio Vieira dos Santos, Pedro Paulo Chieffi, Fabiana Martins de Paula, Ronaldo Cesar Borges Gryschek, Susana Angélica Zevallos Lescano

Abstract

BALB/c mice were inoculated with 5-500 Toxocara canis infective eggs, and bled at 15-120 days post infection (dpi) to evaluate the dynamics of IgG antibody response and larvae distribution. Positive results were observed in all occasions for every inoculum, and a direct proportional relationship between antibody detection and the parasitic load was observed. In samples collected at 60 dpi, detection of IgG was more intense, especially with the 50 and 500 egg doses; also, a correlation between antibody level and egg count was observed with these two inocula. At 120 dpi, a decrease in antibody titer was observed for all groups; and at the end of the experiment, larvae were recovered from carcass, liver and brain. In the liver, larvae were only found in mice inoculated with 500 T. canis eggs. In carcasses, these were recovered in all groups, and the group inoculated with 50 eggs showed the highest percentage of larvae in the brain.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 16 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 2 13%
Student > Postgraduate 2 13%
Other 1 6%
Student > Ph. D. Student 1 6%
Student > Doctoral Student 1 6%
Other 2 13%
Unknown 7 44%
Readers by discipline Count As %
Medicine and Dentistry 3 19%
Agricultural and Biological Sciences 2 13%
Immunology and Microbiology 1 6%
Biochemistry, Genetics and Molecular Biology 1 6%
Unknown 9 56%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 August 2017.
All research outputs
#16,725,651
of 25,382,440 outputs
Outputs from Memórias do Instituto Oswaldo Cruz
#975
of 1,502 outputs
Outputs of similar age
#196,464
of 323,059 outputs
Outputs of similar age from Memórias do Instituto Oswaldo Cruz
#8
of 17 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,502 research outputs from this source. They receive a mean Attention Score of 4.6. This one is in the 32nd percentile – i.e., 32% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 323,059 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.