↓ Skip to main content

Structural insights into leishmanolysins encoded on chromosome 10 of Leishmania (Viannia) braziliensis

Overview of attention for article published in Memórias do Instituto Oswaldo Cruz, September 2017
Altmetric Badge

Mentioned by

twitter
2 X users

Citations

dimensions_citation
8 Dimensions

Readers on

mendeley
23 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Structural insights into leishmanolysins encoded on chromosome 10 of Leishmania (Viannia) braziliensis
Published in
Memórias do Instituto Oswaldo Cruz, September 2017
DOI 10.1590/0074-02760160522
Pubmed ID
Authors

Amanda Sutter, Deborah Antunes, Mariana Silva-Almeida, Maurício Garcia de Souza Costa, Ernesto Raul Caffarena

Abstract

Leishmanolysins have been described as important parasite virulence factors because of their roles in the infection of promastigotes and resistance to host's defenses. Leishmania (Viannia) braziliensis contains several leishmanolysin genes in its genome, especially in chromosome 10. However, the functional impact of such diversity is not understood, but may be attributed partially to the lack of structural data for proteins from this parasite. This works aims to compare leishmanolysin sequences from L. (V.) braziliensis and to understand how the diversity impacts in their structural and dynamic features. Leishmanolysin sequences were retrieved from GeneDB. Subsequently, 3D models were built using comparative modeling methods and their dynamical behavior was studied using molecular dynamic simulations. We identified three subgroups of leishmanolysins according to sequence variations. These differences directly affect the electrostatic properties of leishmanolysins and the geometry of their active sites. We identified two levels of structural heterogeneity that might be related to the ability of promastigotes to interact with a broad range of substrates. Altogether, the structural plasticity of leishmanolysins may constitute an important evolutionary adaptation rarely explored when considering the virulence of L. (V.) braziliensis parasites.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 23 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 17%
Student > Bachelor 3 13%
Student > Master 3 13%
Student > Ph. D. Student 2 9%
Student > Doctoral Student 1 4%
Other 4 17%
Unknown 6 26%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 9 39%
Agricultural and Biological Sciences 3 13%
Physics and Astronomy 1 4%
Social Sciences 1 4%
Chemistry 1 4%
Other 0 0%
Unknown 8 35%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 November 2017.
All research outputs
#19,951,180
of 25,382,440 outputs
Outputs from Memórias do Instituto Oswaldo Cruz
#1,137
of 1,502 outputs
Outputs of similar age
#236,644
of 324,453 outputs
Outputs of similar age from Memórias do Instituto Oswaldo Cruz
#13
of 21 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,502 research outputs from this source. They receive a mean Attention Score of 4.6. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 324,453 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.