Title |
Effect of secondary infection on epithelialisation and total healing of cutaneous leishmaniasis lesions
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Published in |
Memórias do Instituto Oswaldo Cruz, September 2017
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DOI | 10.1590/0074-02760160557 |
Pubmed ID | |
Authors |
Liliane de Fátima Antonio, Marcelo Rosandiski Lyra, Maurício Naoto Saheki, Armando de Oliveira Schubach, Luciana de Freitas Campos Miranda, Maria de Fátima Madeira, Maria Cristina da Silva Lourenço, Aline Fagundes, Érica Aparecida dos Santos Ribeiro, Leonardo Barreto, Maria Inês Fernandes Pimentel |
Abstract |
Cutaneous leishmaniasis (CL) generally presents with a single or several localised cutaneous ulcers without involvement of mucous membranes. Ulcerated lesions are susceptible to secondary contamination that may slow the healing process. This study verified the influence of non-parasitic wound infection on wound closure (epithelialisation) and total healing. Twenty-five patients with a confirmed diagnosis of CL and ulcerated lesions underwent biopsy of ulcer borders. One direct microbial parameter (germ identification in cultures) and four indirect clinical parameters (secretion, pain, burning sensation, pruritus) were analysed. FINDINGS Biopsies of ten lesions showed secondary infection by one or two microorganisms (Staphylococcus aureus, Pseudomonas aeruginosa, Enterococcus faecalis, Streptococcus pyogenes and Candida parapsilosis). "Secretion" and "burning sensation" influenced epithelialisation time but not total healing time. Positive detection of germs in the ulcer border and "pain" and "pruritus" revealed no influence on wound closure. Our borderline proof of clinical CL ulcer infection inhibiting CL wound healing supports the need to follow antimicrobial stewardship in CL ulcer management, which was recently proposed for all chronic wounds. |
X Demographics
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
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Country | Count | As % |
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Unknown | 64 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 13 | 20% |
Researcher | 10 | 16% |
Student > Master | 4 | 6% |
Student > Doctoral Student | 3 | 5% |
Student > Ph. D. Student | 3 | 5% |
Other | 8 | 13% |
Unknown | 23 | 36% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 8 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 9% |
Biochemistry, Genetics and Molecular Biology | 6 | 9% |
Immunology and Microbiology | 6 | 9% |
Agricultural and Biological Sciences | 4 | 6% |
Other | 10 | 16% |
Unknown | 24 | 38% |