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Tracing the origin of the NS1 A188V substitution responsible for recent enhancement of Zika virus Asian genotype infectivity

Overview of attention for article published in Memórias do Instituto Oswaldo Cruz, September 2017
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Title
Tracing the origin of the NS1 A188V substitution responsible for recent enhancement of Zika virus Asian genotype infectivity
Published in
Memórias do Instituto Oswaldo Cruz, September 2017
DOI 10.1590/0074-02760170299
Pubmed ID
Authors

Edson Delatorre, Daiana Mir, Gonzalo Bello

Abstract

A recent study showed that infectivity of Zika virus (ZIKV) Asian genotype was enhanced by an alanine-to-valine amino acid substitution at residue 188 of the NS1 protein, but the precise time and location of origin of this mutation were not formally estimated. Here, we applied a Bayesian coalescent-based framework to estimate the age and location of the ancestral viral strain carrying the A188V substitution. Our results support that the ancestral ZIKV strain carrying the A188V substitution arose in Southeastern Asia at the early 2000s and circulated in that region for some time (5-10 years) before being disseminated to Southern Pacific islands and the Americas.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 46 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 17%
Student > Ph. D. Student 7 15%
Student > Master 6 13%
Student > Bachelor 5 11%
Student > Doctoral Student 2 4%
Other 6 13%
Unknown 12 26%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 6 13%
Agricultural and Biological Sciences 6 13%
Medicine and Dentistry 5 11%
Immunology and Microbiology 4 9%
Social Sciences 2 4%
Other 7 15%
Unknown 16 35%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 December 2017.
All research outputs
#19,951,180
of 25,382,440 outputs
Outputs from Memórias do Instituto Oswaldo Cruz
#1,137
of 1,502 outputs
Outputs of similar age
#236,180
of 323,619 outputs
Outputs of similar age from Memórias do Instituto Oswaldo Cruz
#13
of 21 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,502 research outputs from this source. They receive a mean Attention Score of 4.6. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
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We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.