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Red blood cells derived from peripheral blood and bone marrow CD34+ human haematopoietic stem cells are permissive to Plasmodium parasites infection

Overview of attention for article published in Memórias do Instituto Oswaldo Cruz, September 2013
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42 Mendeley
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Title
Red blood cells derived from peripheral blood and bone marrow CD34+ human haematopoietic stem cells are permissive to Plasmodium parasites infection
Published in
Memórias do Instituto Oswaldo Cruz, September 2013
DOI 10.1590/0074-0276108062013019
Pubmed ID
Authors

Carmen Fernandez-Becerra, Joel Lelievre, Mireia Ferrer, Nuria Anton, Richard Thomson, Cristina Peligero, Maria Jesus Almela, Marcus VG Lacerda, Esperanza Herreros, Hernando A del Portillo

Abstract

The production of fully functional human red cells in vitro from haematopoietic stem cells (hHSCs) has been successfully achieved. Recently, the use of hHSCs from cord blood represented a major improvement to develop the continuous culture system for Plasmodium vivax. Here, we demonstrated that CD34⁺ hHSCs from peripheral blood and bone marrow can be expanded and differentiated to reticulocytes using a novel stromal cell. Moreover, these reticulocytes and mature red blood cells express surface markers for entrance of malaria parasites contain adult haemoglobin and are also permissive to invasion by P. vivax and Plasmodium falciparum parasites.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 2 5%
Peru 1 2%
United Kingdom 1 2%
Unknown 38 90%

Demographic breakdown

Readers by professional status Count As %
Researcher 15 36%
Student > Ph. D. Student 10 24%
Student > Master 6 14%
Student > Bachelor 3 7%
Professor 3 7%
Other 3 7%
Unknown 2 5%
Readers by discipline Count As %
Agricultural and Biological Sciences 16 38%
Medicine and Dentistry 13 31%
Biochemistry, Genetics and Molecular Biology 4 10%
Pharmacology, Toxicology and Pharmaceutical Science 2 5%
Computer Science 1 2%
Other 2 5%
Unknown 4 10%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 December 2013.
All research outputs
#22,756,649
of 25,371,288 outputs
Outputs from Memórias do Instituto Oswaldo Cruz
#1,299
of 1,502 outputs
Outputs of similar age
#189,050
of 212,459 outputs
Outputs of similar age from Memórias do Instituto Oswaldo Cruz
#14
of 23 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,502 research outputs from this source. They receive a mean Attention Score of 4.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 212,459 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.