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A new survey of the serology of human Trypanosoma cruziinfection in the Rio Negro microregion, Brazilian Amazon: a critical analysis

Overview of attention for article published in Memórias do Instituto Oswaldo Cruz, November 2013
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Title
A new survey of the serology of human Trypanosoma cruziinfection in the Rio Negro microregion, Brazilian Amazon: a critical analysis
Published in
Memórias do Instituto Oswaldo Cruz, November 2013
DOI 10.1590/0074-0276130303
Pubmed ID
Authors

José Rodrigues Coura, Maurício Humberto Peña Marquez, Jorge Augusto de Oliveira Guerra, Patricia Lago Zauza, Julio Cesar Miguel, José Borges Pereira

Abstract

The serology of human Trypanosoma cruzi infection in the Rio Negro microregion is very complex because of the large numbers of false-positive cases that result from low antibody titres and cross-reactions with other infections. In the present study, we collected 4,880 blood samples on filter paper; of these, indirect immunofluorescence (IIF) was strongly reactive in 221 (4.5%), which were considered to be positive (IIF strongly reactive; high intensity of fluorescence) and weakly reactive in 302 (6.2%), which were considered to be doubtful (IIF weakly reactive; low intensity of fluorescence). The confirmatory test on the serum using at least two of three techniques (IIF, conventional ELISA and recombinant ELISA) on 137 samples that were positive in the screening test only confirmed 33 cases (24.1%). Of the 178 samples that were considered doubtful in the screening test, only 10 (5.6%) were considered to be positive in the confirmatory test. Finally, we recommend that the serological diagnosis of T. cruzi infection in the Amazon region be made using at least two different techniques, for example immunofluorescence and ELISA and confirmed by Western blot analysis when possible.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mexico 1 4%
Brazil 1 4%
Unknown 25 93%

Demographic breakdown

Readers by professional status Count As %
Student > Master 6 22%
Researcher 5 19%
Student > Doctoral Student 3 11%
Student > Bachelor 2 7%
Student > Ph. D. Student 2 7%
Other 4 15%
Unknown 5 19%
Readers by discipline Count As %
Medicine and Dentistry 5 19%
Agricultural and Biological Sciences 5 19%
Immunology and Microbiology 4 15%
Pharmacology, Toxicology and Pharmaceutical Science 2 7%
Chemistry 2 7%
Other 2 7%
Unknown 7 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 September 2014.
All research outputs
#20,237,640
of 22,764,165 outputs
Outputs from Memórias do Instituto Oswaldo Cruz
#1,181
of 1,375 outputs
Outputs of similar age
#186,170
of 213,721 outputs
Outputs of similar age from Memórias do Instituto Oswaldo Cruz
#13
of 16 outputs
Altmetric has tracked 22,764,165 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,375 research outputs from this source. They receive a mean Attention Score of 4.4. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 213,721 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.