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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Drug discovery for Chagas disease should consider Trypanosoma cruzi strain diversity
|
|---|---|
| Published in |
Memórias do Instituto Oswaldo Cruz, August 2014
|
| DOI | 10.1590/0074-0276140156 |
| Pubmed ID | |
| Authors |
Bianca Zingales, Michael A Miles, Carolina B Moraes, Alejandro Luquetti, Felipe Guhl, Alejandro G Schijman, Isabela Ribeiro |
| Abstract |
This opinion piece presents an approach to standardisation of an important aspect of Chagas disease drug discovery and development: selecting Trypanosoma cruzi strains for in vitro screening. We discuss the rationale for strain selection representing T. cruzi diversity and provide recommendations on the preferred parasite stage for drug discovery, T. cruzi discrete typing units to include in the panel of strains and the number of strains/clones for primary screens and lead compounds. We also consider experimental approaches for in vitro drug assays. The Figure illustrates the current Chagas disease drug-discovery and development landscape. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Argentina | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 202 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Mexico | 1 | <1% |
| India | 1 | <1% |
| Argentina | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 198 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 32 | 16% |
| Student > Master | 31 | 15% |
| Student > Ph. D. Student | 28 | 14% |
| Student > Doctoral Student | 20 | 10% |
| Student > Bachelor | 17 | 8% |
| Other | 33 | 16% |
| Unknown | 41 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 40 | 20% |
| Agricultural and Biological Sciences | 30 | 15% |
| Medicine and Dentistry | 21 | 10% |
| Chemistry | 21 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 16 | 8% |
| Other | 25 | 12% |
| Unknown | 49 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 June 2022.
All research outputs
#7,355,485
of 25,371,288 outputs
Outputs from Memórias do Instituto Oswaldo Cruz
#257
of 1,502 outputs
Outputs of similar age
#67,474
of 247,497 outputs
Outputs of similar age from Memórias do Instituto Oswaldo Cruz
#10
of 31 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 1,502 research outputs from this source. They receive a mean Attention Score of 4.6. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 247,497 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 31 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.