Title |
Genetic diversity of chloroquine-resistant Plasmodium vivax parasites from the western Brazilian Amazon
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Published in |
Memórias do Instituto Oswaldo Cruz, November 2014
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DOI | 10.1590/0074-0276140241 |
Pubmed ID | |
Authors |
Omaira Vera Lizcano, Sarah Stela Resende, Yonne F Chehuan, Marcus VG Lacerda, Cristiana FA Brito, Mariano G Zalis |
Abstract |
The molecular basis of Plasmodium vivax chloroquine (CQ) resistance is still unknown. Elucidating the molecular background of parasites that are sensitive or resistant to CQ will help to identify and monitor the spread of resistance. By genotyping a panel of molecular markers, we demonstrate a similar genetic variability between in vitro CQ-resistant and sensitive phenotypes of P. vivax parasites. However, our studies identified two loci (MS8 and MSP1-B10) that could be used to discriminate between both CQ-susceptible phenotypes among P. vivax isolates in vitro. These preliminary data suggest that microsatellites may be used to identify and to monitor the spread of P. vivax-resistance around the world. |
X Demographics
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 3% |
Unknown | 31 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 8 | 25% |
Student > Master | 6 | 19% |
Student > Postgraduate | 3 | 9% |
Student > Doctoral Student | 2 | 6% |
Researcher | 2 | 6% |
Other | 6 | 19% |
Unknown | 5 | 16% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 9 | 28% |
Agricultural and Biological Sciences | 6 | 19% |
Biochemistry, Genetics and Molecular Biology | 3 | 9% |
Engineering | 2 | 6% |
Immunology and Microbiology | 2 | 6% |
Other | 3 | 9% |
Unknown | 7 | 22% |