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Effect of Low-Level Laser Therapy (λ660 nm) on Angiogenesis in Wound Healing: A Immunohistochemical Study in a Rodent Model

Overview of attention for article published in Brazilian Dental Journal, July 2013
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Title
Effect of Low-Level Laser Therapy (λ660 nm) on Angiogenesis in Wound Healing: A Immunohistochemical Study in a Rodent Model
Published in
Brazilian Dental Journal, July 2013
DOI 10.1590/0103-6440201301867
Pubmed ID
Authors

Fábio Colombo, Alberto de Aguiar Pires Valença Neto, Ana Paula Cavalcanti de Sousa, Antônio Márcio Teixeira Marchionni, Antônio Luiz Barbosa Pinheiro, Silvia Regina de Almeida Reis

Abstract

The aim of the present investigation was to evaluate the angiogenesis on dorsal cutaneous wounds in a rodent model treated with λ660 nm laser light. New vessel formation is a multistep process involving vessel sprouting, endothelial cell migration, proliferation and tube formation. Although several in vivo studies have shown that laser phototherapy influences tissue repair, a fully understanding of angiogenesis mechanisms are not yet known. Twenty-four young adult male Wistar rats weighing between 200 and 250 g were used. Under general anesthesia, one excisional wound was created on the dorsum of each animal and they were randomly distributed into two groups: one control and one treated with laser (λ660 nm, 16 mW, 10 J/cm2). Each group was subdivided into three subgroups according to the animal death timing (2, 4 and 6 days). Laser irradiation started immediately after surgery and was repeated every other day during the experiment and marked with Sirius Red, specific for collagen, and immunomarked with anti-TGF-β and anti-von Willebrand factor. Marked sections underwent histological analysis by light microscopy and the mean area of the wound of each animal was calculated and analyzed by ANOVA and Tukey's test (α=0.05). Although at some death periods, collagen expression and number of blood vessels on irradiated animals were higher than in the control ones, no significant differences were found at any time in relation to TGF-β expression (p>0.05). It was concluded that laser treatment (λ660 nm) contributed to increase angiogenesis.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 69 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Austria 1 1%
Unknown 68 99%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 10 14%
Student > Master 9 13%
Student > Postgraduate 8 12%
Student > Ph. D. Student 6 9%
Professor 4 6%
Other 14 20%
Unknown 18 26%
Readers by discipline Count As %
Medicine and Dentistry 22 32%
Nursing and Health Professions 5 7%
Agricultural and Biological Sciences 5 7%
Biochemistry, Genetics and Molecular Biology 2 3%
Veterinary Science and Veterinary Medicine 2 3%
Other 11 16%
Unknown 22 32%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 December 2015.
All research outputs
#15,168,964
of 25,373,627 outputs
Outputs from Brazilian Dental Journal
#84
of 284 outputs
Outputs of similar age
#112,922
of 206,705 outputs
Outputs of similar age from Brazilian Dental Journal
#1
of 5 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 38th percentile – i.e., 38% of other outputs scored the same or lower than it.
So far Altmetric has tracked 284 research outputs from this source. They receive a mean Attention Score of 2.6. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 206,705 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them