Title |
Radioprotective Effect of Sodium Selenite on Developing Teeth
|
---|---|
Published in |
Brazilian Dental Journal, July 2013
|
DOI | 10.1590/0103-6440201302193 |
Pubmed ID | |
Authors |
Ellen Gaby Neves, Flávia Maria de Moraes Ramos-Perez, Deborah Queiroz Freitas, Frab Norberto Bóscolo, Solange Maria Almeida |
Abstract |
Radioprotective agents like selenium are used to reduce the damage caused by radiation in healthy tissues. The aim of this study was to evaluate the effect of sodium selenite on the development of the molars of offspring of rats irradiated during odontogenesis. Twenty pregnant rats were randomly divided into 4 groups: control, irradiated, selenium and selenium/irradiated. The selenium and selenium/irradiated groups received 0.3 mg/kg of sodium selenite at 18 days of pregnancy. The rats of the irradiated and selenium/irradiated groups received a single dose of 4 Gy of X rays on the abdominal region at the 19th day of pregnancy. The offspring was sacrificed at 3 and 4 days after birth for evaluation of the birefringence of the enamel organic matrix, and at 30 days for evaluation of the intercuspal dimensions of the molars. The selenium/irradiated group was similar to the irradiated group with respect to the thickness and irregularity of the enamel organic matrix region in the evaluated birefringence, as the intercuspal dimensions of the molars. In conclusion, sodium selenite had no radioprotective action on the development of the molars of offspring of rats irradiated during odontogenesis and had a toxic effect in the initial time. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 21 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 4 | 19% |
Student > Postgraduate | 2 | 10% |
Researcher | 2 | 10% |
Student > Ph. D. Student | 2 | 10% |
Other | 1 | 5% |
Other | 3 | 14% |
Unknown | 7 | 33% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 7 | 33% |
Biochemistry, Genetics and Molecular Biology | 5 | 24% |
Agricultural and Biological Sciences | 1 | 5% |
Nursing and Health Professions | 1 | 5% |
Unknown | 7 | 33% |