Title |
Rosmarinus officinalis L. increases Caenorhabditis elegans stress resistance and longevity in a DAF-16, HSF-1 and SKN-1-dependent manner
|
---|---|
Published in |
Brazilian Journal of Medical and Biological Research, January 2016
|
DOI | 10.1590/1414-431x20165235 |
Pubmed ID | |
Authors |
D.C. Zamberlan, G.P. Amaral, L.P. Arantes, M.L. Machado, C.R. Mizdal, M.M.A. Campos, F.A.A. Soares |
Abstract |
Improving overall health and quality of life, preventing diseases and increasing life expectancy are key concerns in the field of public health. The search for antioxidants that can inhibit oxidative damage in cells has received a lot of attention. Rosmarinus officinalis L. represents an exceptionally rich source of bioactive compounds with pharmacological properties. In the present study, we explored the effects of the ethanolic extract of R. officinalis (eeRo) on stress resistance and longevity using the non-parasitic nematode Caenorhabditis elegans as a model. We report for the first time that eeRo increased resistance against oxidative and thermal stress and extended C. elegans longevity in an insulin/IGF signaling pathway-dependent manner. These data emphasize the eeRo beneficial effects on C. elegans under stress. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 3 | 38% |
United Kingdom | 2 | 25% |
Unknown | 3 | 38% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 6 | 75% |
Science communicators (journalists, bloggers, editors) | 1 | 13% |
Practitioners (doctors, other healthcare professionals) | 1 | 13% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 46 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 10 | 22% |
Student > Ph. D. Student | 6 | 13% |
Researcher | 5 | 11% |
Student > Bachelor | 3 | 7% |
Student > Doctoral Student | 2 | 4% |
Other | 8 | 17% |
Unknown | 12 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 10 | 22% |
Biochemistry, Genetics and Molecular Biology | 8 | 17% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
Nursing and Health Professions | 2 | 4% |
Immunology and Microbiology | 2 | 4% |
Other | 5 | 11% |
Unknown | 17 | 37% |