Title |
Risk factors for hospitalization and death due to COVID-19 among frail community-dwelling elderly people: a retrospective cohort study
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Published in |
Sao Paulo Medical Journal, August 2022
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DOI | 10.1590/1516-3180.2021.0649.r1.20122021 |
Pubmed ID | |
Authors |
Daniela Castelo Azevedo, Fernando César Menezes Assunção, Mônica Silva Monteiro de Castro, Estevão Alves Valle |
Abstract |
Advanced age, multiple chronic diseases and frailty have been correlated with worse prognosis among coronavirus disease 2019 (COVID-19) inpatients. To investigate potential risk factors for hospitalization and death due to COVID-19 among frail community-dwelling elderly people. Retrospective cohort study of patients followed up at a geriatric outpatient clinic in Belo Horizonte, Minas Gerais, Brazil. The associations of demographic characteristics (age and sex) and clinical characteristics (frailty, multimorbidity, number of medications with long-term use, obesity, smoking, diabetes mellitus, pulmonary diseases, cardiovascular diseases, cerebrovascular disease, and chronic kidney disease) with the risk of hospitalization and death due to COVID-19 were explored using a multivariable logistic regression model. 5,295 patients (mean age 78.6 ± 9.4 years; 72.6% females) were included. After adjustments, the number of medications with long-term use was found to increase the odds of hospitalization due to COVID-19 (odds ratio, OR: 1.13; 95% confidence interval, CI: 1.06-1.22). Frailty, multimorbidity and diabetes mellitus also increased the odds of hospitalization (OR: 1.06, 95% CI: 1.02-1.09; OR: 1.17, 95% CI: 1.09-1.26; and OR: 2.27, 95% CI: 1.45-3.54, respectively) and the odds of death due to COVID-19 (OR: 1.07, 95% CI: 1.00-1.14; OR: 1.16, 95% CI: 1.03-1.32; and OR: 2.69, 95% CI: 1.79-6.14, respectively). Multimorbidity, frailty and diabetes mellitus increased the odds of hospitalization and death due to COVID-19 and the number of medications with long-term use increased the odds of hospitalization due to COVID-19 among frail community-dwelling elderly people. |
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Country | Count | As % |
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Unknown | 37 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 9 | 24% |
Student > Doctoral Student | 2 | 5% |
Student > Bachelor | 2 | 5% |
Librarian | 1 | 3% |
Student > Ph. D. Student | 1 | 3% |
Other | 1 | 3% |
Unknown | 21 | 57% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 2 | 5% |
Nursing and Health Professions | 2 | 5% |
Veterinary Science and Veterinary Medicine | 1 | 3% |
Other | 2 | 5% |
Unknown | 25 | 68% |