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Risk factors for hospitalization and death due to COVID-19 among frail community-dwelling elderly people: a retrospective cohort study

Overview of attention for article published in Sao Paulo Medical Journal, August 2022
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Title
Risk factors for hospitalization and death due to COVID-19 among frail community-dwelling elderly people: a retrospective cohort study
Published in
Sao Paulo Medical Journal, August 2022
DOI 10.1590/1516-3180.2021.0649.r1.20122021
Pubmed ID
Authors

Daniela Castelo Azevedo, Fernando César Menezes Assunção, Mônica Silva Monteiro de Castro, Estevão Alves Valle

Abstract

Advanced age, multiple chronic diseases and frailty have been correlated with worse prognosis among coronavirus disease 2019 (COVID-19) inpatients. To investigate potential risk factors for hospitalization and death due to COVID-19 among frail community-dwelling elderly people. Retrospective cohort study of patients followed up at a geriatric outpatient clinic in Belo Horizonte, Minas Gerais, Brazil. The associations of demographic characteristics (age and sex) and clinical characteristics (frailty, multimorbidity, number of medications with long-term use, obesity, smoking, diabetes mellitus, pulmonary diseases, cardiovascular diseases, cerebrovascular disease, and chronic kidney disease) with the risk of hospitalization and death due to COVID-19 were explored using a multivariable logistic regression model. 5,295 patients (mean age 78.6 ± 9.4 years; 72.6% females) were included. After adjustments, the number of medications with long-term use was found to increase the odds of hospitalization due to COVID-19 (odds ratio, OR: 1.13; 95% confidence interval, CI: 1.06-1.22). Frailty, multimorbidity and diabetes mellitus also increased the odds of hospitalization (OR: 1.06, 95% CI: 1.02-1.09; OR: 1.17, 95% CI: 1.09-1.26; and OR: 2.27, 95% CI: 1.45-3.54, respectively) and the odds of death due to COVID-19 (OR: 1.07, 95% CI: 1.00-1.14; OR: 1.16, 95% CI: 1.03-1.32; and OR: 2.69, 95% CI: 1.79-6.14, respectively). Multimorbidity, frailty and diabetes mellitus increased the odds of hospitalization and death due to COVID-19 and the number of medications with long-term use increased the odds of hospitalization due to COVID-19 among frail community-dwelling elderly people.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 37 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 9 24%
Student > Doctoral Student 2 5%
Student > Bachelor 2 5%
Librarian 1 3%
Student > Ph. D. Student 1 3%
Other 1 3%
Unknown 21 57%
Readers by discipline Count As %
Medicine and Dentistry 3 8%
Environmental Science 2 5%
Biochemistry, Genetics and Molecular Biology 2 5%
Nursing and Health Professions 2 5%
Veterinary Science and Veterinary Medicine 1 3%
Other 2 5%
Unknown 25 68%