Title |
Decreased plasma neurotrophin-4/5 levels in bipolar disorder patients in mania
|
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Published in |
Revista Brasileira de Psiquiatria, July 2014
|
DOI | 10.1590/1516-4446-2014-1380 |
Pubmed ID | |
Authors |
Izabela G Barbosa, Isabela B Morato, Rodrigo B Huguet, Fabio L Rocha, Rodrigo Machado-Vieira, Antônio L Teixeira |
Abstract |
Objective: To evaluate two poorly explored neurotrophins (NT), NT-3 and NT-4/5, in bipolar disorder (BD). Methods: Forty patients with type I BD (18 in remission and 22 in mania) and 25 healthy controls matched for age, gender, and educational attainment were enrolled in this study. All subjects were assessed by the Mini-International Neuropsychiatric Interview; the Young Mania Rating Scale and the Hamilton Depression Rating Scale were used to evaluate severity of symptoms in BD patients. Plasma levels of NT-3 and NT-4/5 were measured by enzyme-linked immunosorbent assay (ELISA). Results: BD patients in mania presented decreased NT-4/5 plasma levels in comparison with controls (p < 0.05). There were no significant differences in NT-3 plasma levels between BD patients and controls. Conclusion: These findings corroborate the view that neurotrophin dysfunction is associated with mood states in patients with BD. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 39 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 5 | 13% |
Student > Bachelor | 4 | 10% |
Student > Master | 3 | 8% |
Student > Ph. D. Student | 3 | 8% |
Student > Doctoral Student | 2 | 5% |
Other | 6 | 15% |
Unknown | 16 | 41% |
Readers by discipline | Count | As % |
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Psychology | 4 | 10% |
Agricultural and Biological Sciences | 3 | 8% |
Biochemistry, Genetics and Molecular Biology | 2 | 5% |
Arts and Humanities | 2 | 5% |
Other | 6 | 15% |
Unknown | 16 | 41% |