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Mendeley readers
Attention Score in Context
| Title |
Hypericum perforatum chronic treatment affects cognitive parameters and brain neurotrophic factor levels
|
|---|---|
| Published in |
Revista Brasileira de Psiquiatria, August 2018
|
| DOI | 10.1590/1516-4446-2017-2271 |
| Pubmed ID | |
| Authors |
Samira S. Valvassori, Cenita Borges, Daniela V. Bavaresco, Roger B. Varela, Wilson R. Resende, Bruna R. Peterle, Camila O. Arent, Josiane Budni, João Quevedo |
| Abstract |
To evaluate the effects of Hypericum perforatum (hypericum) on cognitive behavior and neurotrophic factor levels in the brain of male and female rats. Male and female Wistar rats were treated with hypericum or water during 28 days by gavage. The animals were then subjected to the open-field test, novel object recognition and step-down inhibitory avoidance test. Nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and glial cell-line derived neurotrophic factor (GDNF) levels were evaluated in the hippocampus and frontal cortex. Hypericum impaired the acquisition of short- and long-term aversive memory in male rats, evaluated in the inhibitory avoidance test. Female rats had no immediate memory acquisition and decreased short-term memory acquisition in the inhibitory avoidance test. Hypericum also decreased the recognition index of male rats in the object recognition test. Female rats did not recognize the new object in either the short-term or the long-term memory tasks. Hypericum decreased BDNF in the hippocampus of male and female rats. Hypericum also decreased NGF in the hippocampus of female rats. The long-term administration of hypericum appears to cause significant cognitive impairment in rats, possibly through a reduction in the levels of neurotrophic factors. This effect was more expressive in females than in males. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 30 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 6 | 20% |
| Student > Ph. D. Student | 3 | 10% |
| Professor > Associate Professor | 2 | 7% |
| Researcher | 2 | 7% |
| Professor | 1 | 3% |
| Other | 3 | 10% |
| Unknown | 13 | 43% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 3 | 10% |
| Biochemistry, Genetics and Molecular Biology | 3 | 10% |
| Nursing and Health Professions | 2 | 7% |
| Medicine and Dentistry | 2 | 7% |
| Neuroscience | 2 | 7% |
| Other | 4 | 13% |
| Unknown | 14 | 47% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 September 2018.
All research outputs
#22,767,715
of 25,385,509 outputs
Outputs from Revista Brasileira de Psiquiatria
#792
of 903 outputs
Outputs of similar age
#298,575
of 341,399 outputs
Outputs of similar age from Revista Brasileira de Psiquiatria
#1
of 3 outputs
Altmetric has tracked 25,385,509 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 903 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.9. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 341,399 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them