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Potential antidepressant effect of amantadine: a review of preclinical studies and clinical trials

Overview of attention for article published in Revista Brasileira de Psiquiatria, June 2018
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (83rd percentile)
  • High Attention Score compared to outputs of the same age and source (80th percentile)

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1 news outlet
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7 X users

Citations

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29 Dimensions

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59 Mendeley
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Title
Potential antidepressant effect of amantadine: a review of preclinical studies and clinical trials
Published in
Revista Brasileira de Psiquiatria, June 2018
DOI 10.1590/1516-4446-2017-2393
Pubmed ID
Authors

Inara F. Raupp-Barcaro, Maria A. Vital, José C. Galduróz, Roberto Andreatini

Abstract

Amantadine blocks N-methyl-D-aspartate (NMDA) receptors and has dopaminergic and noradrenergic action, a neurochemical profile that suggests its potential as an antidepressant drug. We conducted a systematic review of preclinical and clinical studies addressing the effects of amantadine in animal models of depression and in patients with depression. PubMed, Science Direct, and Web of Science were searched up to September 1, 2017 to identify clinical and preclinical studies. The following search terms were used: "amantadine AND depress*"; "amantadine AND mood"; "amantadine AND animal models AND antidepres*"; and "amantadine AND (forced swim, learned helplessness, reserpine, chronic mild stress, anhedonia, sucrose preference)." Amantadine had antidepressant-like effects in animal models and appeared to potentiate the antidepressant effects of other antidepressants. These preclinical findings have received some support from the results of small open-label clinical trials, suggesting that amantadine can reduce depressive symptomatology and potentiate the antidepressant effects of monoaminergic drugs. In addition to its glutamatergic and dopaminergic effects, the potential antidepressant-like effects of amantadine have been linked to molecular and cellular actions, such as increased expression of neurotrophic factors (e.g., brain-derived neurotrophic factor), activation of σ1 receptors, decreased corticosterone levels, and decreased inflammatory response to stress. Amantadine is an interesting candidate as new antidepressant drug for the treatment of depression.

X Demographics

X Demographics

The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 59 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 10 17%
Student > Master 9 15%
Researcher 7 12%
Other 5 8%
Student > Ph. D. Student 4 7%
Other 9 15%
Unknown 15 25%
Readers by discipline Count As %
Medicine and Dentistry 14 24%
Neuroscience 6 10%
Pharmacology, Toxicology and Pharmaceutical Science 5 8%
Psychology 5 8%
Agricultural and Biological Sciences 4 7%
Other 9 15%
Unknown 16 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 May 2023.
All research outputs
#2,761,243
of 25,382,440 outputs
Outputs from Revista Brasileira de Psiquiatria
#88
of 903 outputs
Outputs of similar age
#54,926
of 341,432 outputs
Outputs of similar age from Revista Brasileira de Psiquiatria
#1
of 5 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 903 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.9. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 341,432 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them