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Attention Score in Context
| Title |
Orthotopic tumorgrafts in nude mice as a model to evaluate calcitriol effects in breast cancer
|
|---|---|
| Published in |
Brazilian Journal of Biology, May 2017
|
| DOI | 10.1590/1519-6984.04016 |
| Pubmed ID | |
| Authors |
V. C. N. Fonseca-Filho, M. L. H. Katayama, E. C. Lyra, D. A. Maria, R. A. Basso, S. Nonogaki, J. M. Guerra, S. Maistro, J. C. G. S. Góes, M. A. A. K. Folgueira |
| Abstract |
To establish a tumorgraft model, from freshly collected breast cancer samples, which were directly implanted in nude mice, to study calcitriol effects. Breast cancer samples collected from 12 patients were orthotopically implanted into nude mice. Animals were treated with weekly intratumoral injections of calcitriol 3 μg/Kg, which was previously shown to induce peak serum calcitriol levels in the predicted therapeutic range. Success engraftment rate was 25%. Tumorgrafts were established from aggressive (HER2 positive or histological grade 3) highly proliferative samples and original tumor characteristics were preserved. Calcitriol highly induced its target gene, CYP24A1, indicating that the genomic vitamin D pathway is active in tumorgrafts. However, no differences in the expression of proliferation and apoptosis markers (BrdU incorporation, Ki67, CDKN1A, CDKN1B, BCL2 expression) were observed in these highly proliferative tumor samples. Tumorgrafts seem a promising model to explore other calcitriol doses and regimens, considering the heterogeneity of the disease and microenvironment interactions. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 May 2017.
All research outputs
#20,420,242
of 22,971,207 outputs
Outputs from Brazilian Journal of Biology
#240
of 291 outputs
Outputs of similar age
#270,640
of 310,951 outputs
Outputs of similar age from Brazilian Journal of Biology
#1
of 2 outputs
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So far Altmetric has tracked 291 research outputs from this source. They receive a mean Attention Score of 3.2. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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