Title |
Vegetable and fruit juice enhances antioxidant capacity and regulates antioxidant gene expression in rat liver, brain and colon
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Published in |
Genetics and Molecular Biology, March 2017
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DOI | 10.1590/1678-4685-gmb-2016-0159 |
Pubmed ID | |
Authors |
Linhong Yuan, Jinmeng Liu, Jie Zhen, Yao Xu, Shuying Chen, Nicholas Van Halm-Lutterodt, Rong Xiao |
Abstract |
To explore the effect of fruit and vegetable (FV) juice on biomarkers of oxidative damage and antioxidant gene expression in rats, 36 adult male Wistar rats were randomly divided into control, low FV juice dosage or high FV juice dosage treatment groups. The rats were given freshly extracted FV juice or the same volume of saline water daily for five weeks. After intervention, serum and tissues specimens were collected for biomarker and gene expression measurement. FV juice intervention increased total antioxidant capacity, glutathione, vitamin C, β-carotene, total polyphenols, flavonoids levels andglutathione peroxidaseenzyme activity in rat serum or tissues (p < 0.05). FV juice intervention caused reduction of malondialdehyde levels in rat liver (p < 0.05) and significantly modulated transcript levels of glutamate cysteine ligase catalytic subunit (GCLC) and NAD(P)H:quinone oxidoreductase l (NQO1)in rat liver and brain (p < 0.05). The results underline the potential of FV juice to improve the antioxidant capacity and to prevent the oxidative damage in liver, brain and colon. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 25 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Doctoral Student | 4 | 16% |
Student > Master | 3 | 12% |
Researcher | 2 | 8% |
Student > Bachelor | 1 | 4% |
Professor | 1 | 4% |
Other | 5 | 20% |
Unknown | 9 | 36% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 3 | 12% |
Biochemistry, Genetics and Molecular Biology | 3 | 12% |
Nursing and Health Professions | 2 | 8% |
Unspecified | 1 | 4% |
Veterinary Science and Veterinary Medicine | 1 | 4% |
Other | 2 | 8% |
Unknown | 13 | 52% |