Title |
Oxytocin and arginine vasopressin systems in the domestication process
|
---|---|
Published in |
Genetics and Molecular Biology, March 2018
|
DOI | 10.1590/1678-4685-gmb-2017-0069 |
Pubmed ID | |
Authors |
Bibiana S.O. Fam, Pamela Paré, Aline B. Felkl, Pedro Vargas-Pinilla, Vanessa R. Paixão-Côrtes, Lucas Henriques Viscardi, Maria Cátira Bortolini |
Abstract |
Domestication is of unquestionable importance to the technological revolution that has given rise to modern human societies. In this study, we analyzed the DNA and protein sequences of six genes of the oxytocin and arginine vasopressin systems (OXT-OXTR; AVP-AVPR1a, AVPR1b and AVPR2) in 40 placental mammals. These systems play an important role in the control of physiology and behavior. According to our analyses, neutrality does not explain the pattern of molecular evolution found in some of these genes. We observed specific sites under positive selection in AVPR1b (ω = 1.429, p = 0.001) and AVPR2 (ω= 1.49, p = 0.001), suggesting that they could be involved in behavior and physiological changes, including those related to the domestication process. Furthermore, AVPR1a, which plays a role in social behavior, is under relaxed selective constraint in domesticated species. These results provide new insights into the nature of the domestication process and its impact on the OXT-AVP system. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 50% |
Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 27 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 10 | 37% |
Student > Bachelor | 3 | 11% |
Student > Doctoral Student | 2 | 7% |
Professor | 2 | 7% |
Student > Ph. D. Student | 2 | 7% |
Other | 4 | 15% |
Unknown | 4 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 8 | 30% |
Agricultural and Biological Sciences | 5 | 19% |
Veterinary Science and Veterinary Medicine | 2 | 7% |
Environmental Science | 2 | 7% |
Neuroscience | 2 | 7% |
Other | 2 | 7% |
Unknown | 6 | 22% |