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Absence of TERT promoter mutations in colorectal precursor lesions and cancer

Overview of attention for article published in Genetics and Molecular Biology, February 2018
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Title
Absence of TERT promoter mutations in colorectal precursor lesions and cancer
Published in
Genetics and Molecular Biology, February 2018
DOI 10.1590/1678-4685-gmb-2017-0133
Pubmed ID
Authors

Adriana Cruvinel-Carloni, Letícia Yamane, Cristovam Scapulatempo-Neto, Denise Guimarães, Rui Manuel Reis

Abstract

Hotspot mutations (c.-124bp G > A and c.-146bp G > A) in the promoter region of the TERT gene have been recently described in several types of solid tumors, including glioma, bladder, thyroid, liver and skin neoplasms. However, knowledge with respect to colorectal precursor lesions and cancer is scarce. In the present study we aimed to determine the frequency of hotspot TERT promoter mutations in 145 Brazilian patients, including 103 subjects with precursor lesions and 42 with colorectal carcinomas, and we associated the presence of such mutations with the patients clinical-pathological features. The mutation analysis was conclusive in 123 cases, and none of the precursor and colorectal carcinoma cases showed TERT promoter mutations. We conclude that TERT mutations are not a driving factor in colorectal carcinogenesis.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 18 100%

Demographic breakdown

Readers by professional status Count As %
Other 2 11%
Student > Bachelor 2 11%
Student > Master 2 11%
Student > Doctoral Student 1 6%
Researcher 1 6%
Other 0 0%
Unknown 10 56%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 4 22%
Medicine and Dentistry 3 17%
Unknown 11 61%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 January 2019.
All research outputs
#22,767,715
of 25,382,440 outputs
Outputs from Genetics and Molecular Biology
#647
of 772 outputs
Outputs of similar age
#304,620
of 344,213 outputs
Outputs of similar age from Genetics and Molecular Biology
#13
of 14 outputs
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