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Mendeley readers
Attention Score in Context
| Title |
Cytocompatibility and biocompatibility of nanostructured carbonated hydroxyapatite spheres for bone repair
|
|---|---|
| Published in |
Journal of Applied Oral Science, January 2015
|
| DOI | 10.1590/1678-775720150122 |
| Pubmed ID | |
| Authors |
Mônica Diuana Calasans-Maia, Bruno Raposo de Melo, Adriana Terezinha Neves Novellino Alves, Rodrigo Figueiredo de Brito Resende, Rafael Seabra Louro, Suelen Cristina Sartoretto, José Mauro Granjeiro, Gutemberg Gomes Alves |
| Abstract |
Objective The aim of this study was to investigate the in vitro and in vivo biological responses to nanostructured carbonated hydroxyapatite/calcium alginate (CHA) microspheres used for alveolar bone repair, compared to sintered hydroxyapatite (HA). Material and Methods The maxillary central incisors of 45 Wistar rats were extracted, and the dental sockets were filled with HA, CHA, and blood clot (control group) (n=5/period/group). After 7, 21 and 42 days, the samples of bone with the biomaterials were obtained for histological and histomorphometric analysis, and the plasma levels of RANKL and OPG were determined via immunoassay. Statistical analysis was performed by Two-Way ANOVA with post-hoc Tukey test at 95% level of significance. Results The CHA and HA microspheres were cytocompatible with both human and murine cells on an in vitro assay. Histological analysis showed the time-dependent increase of newly formed bone in control group characterized by an intense osteoblast activity. In HA and CHA groups, the presence of a slight granulation reaction around the spheres was observed after seven days, which was reduced by the 42nd day. A considerable amount of newly formed bone was observed surrounding the CHA spheres and the biomaterials particles at 42-day time point compared with HA. Histomorphometric analysis showed a significant increase of newly formed bone in CHA group compared with HA after 21 and 42 days from surgery, moreover, CHA showed almost 2-fold greater biosorption than HA at 42 days (two-way ANOVA, p<0.05) indicating greater biosorption. An increase in the RANKL/OPG ratio was observed in the CHA group on the 7th day. Conclusion CHA spheres were osteoconductive and presented earlier biosorption, inducing early increases in the levels of proteins involved in resorption. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 105 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Latvia | 1 | <1% |
| Unknown | 104 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 16 | 15% |
| Student > Master | 13 | 12% |
| Student > Postgraduate | 12 | 11% |
| Student > Doctoral Student | 10 | 10% |
| Researcher | 8 | 8% |
| Other | 13 | 12% |
| Unknown | 33 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 19 | 18% |
| Chemistry | 9 | 9% |
| Engineering | 9 | 9% |
| Materials Science | 9 | 9% |
| Biochemistry, Genetics and Molecular Biology | 7 | 7% |
| Other | 17 | 16% |
| Unknown | 35 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 January 2016.
All research outputs
#22,759,802
of 25,374,917 outputs
Outputs from Journal of Applied Oral Science
#496
of 596 outputs
Outputs of similar age
#306,548
of 359,538 outputs
Outputs of similar age from Journal of Applied Oral Science
#22
of 33 outputs
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So far Altmetric has tracked 596 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 33 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.