Title |
Latent tuberculosis infection in patients with rheumatic diseases
|
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Published in |
Jornal de Pneumologia, January 2019
|
DOI | 10.1590/1806-3713/e20190023 |
Pubmed ID | |
Authors |
Camila Anton, Felipe Dominguez Machado, Jorge Mario Ahumada Ramirez, Rafaela Manzoni Bernardi, Penélope Esther Palominos, Claiton Viegas Brenol, Fernanda Carvalho de Queiroz Mello, Denise Rossato Silva |
Abstract |
Most people infected by Mycobacterium tuberculosis (Mtb) do not have any signs or disease symptoms, a condition known as latent tuberculosis infection (LTBI). The introduction of biological agents, mainly tumor necrosis factor (TNF) inhibitors, for the treatment of immune-mediated diseases such as Rheumatoid Arthritis (RA) and other rheumatic diseases, increased the risk of reactivation of LTBI, leading to development of active TB. Thus, this review will approach the aspects related to LTBI in patients with rheumatologic diseases, especially those using iTNF drugs. For this purpose it will be considered the definition and prevalence of LTBI, mechanisms associated with diseases and medications in use, criteria for screening, diagnosis and treatment. Considering that reactivation of LTBI accounts for a large proportion of the incidence of active TB, adequate diagnosis and treatment are crucial, especially in high-risk groups such as patients with rheumatologic diseases. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 69 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 11 | 16% |
Researcher | 6 | 9% |
Student > Master | 5 | 7% |
Student > Doctoral Student | 4 | 6% |
Student > Ph. D. Student | 3 | 4% |
Other | 12 | 17% |
Unknown | 28 | 41% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 22 | 32% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 6% |
Biochemistry, Genetics and Molecular Biology | 4 | 6% |
Nursing and Health Professions | 3 | 4% |
Computer Science | 2 | 3% |
Other | 4 | 6% |
Unknown | 30 | 43% |