Title |
MicroRNAs, cancer and ionizing radiation: Where are we?
|
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Published in |
Revista da Associação Médica Brasileira, June 2015
|
DOI | 10.1590/1806-9282.61.03.275 |
Pubmed ID | |
Authors |
Gustavo Nader Marta, Bernardo Garicochea, André Lopes Carvalho, Juliana M. Real, Luiz Paulo Kowalski |
Abstract |
The aim of this study is to describe the biogenesis of microRNA, its relations with carcinogenesis, and the correlation between microRNA and ionizing radiation (IR), focusing on radioresponsiveness. It is known that microRNA biogenesis is well established and involves different enzymatic cleavages, resulting in the production of mature microRNA. MicroRNAs are involved in carcinogenesis. Their interaction is related to the genetic and epigenetic changes associated with activation of proto-oncogenes or inactivation of tumor suppressor genes. Several studies have shown that the levels of expression of some microRNAs vary significantly after irradiation. There are evidences that microRNAs can influence cellular response after IR. In addition, microRNAs are related to modulation of the expression of several post-transcriptional targets in DNA damage response pathways, and to the DNA damage repair regulation mechanism. Future studies can clarify a possible clinical use of microRNAs as a new class of radiosensitive agents. |
X Demographics
Geographical breakdown
Country | Count | As % |
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France | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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India | 1 | 3% |
Unknown | 35 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 9 | 25% |
Student > Master | 6 | 17% |
Researcher | 5 | 14% |
Student > Doctoral Student | 3 | 8% |
Student > Bachelor | 1 | 3% |
Other | 1 | 3% |
Unknown | 11 | 31% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 10 | 28% |
Biochemistry, Genetics and Molecular Biology | 7 | 19% |
Medicine and Dentistry | 4 | 11% |
Arts and Humanities | 1 | 3% |
Immunology and Microbiology | 1 | 3% |
Other | 1 | 3% |
Unknown | 12 | 33% |