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Single-nucleotide polymorphisms: a perspective of cardiovascular prevention

Overview of attention for article published in Revista da Associação Médica Brasileira, October 2015
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Title
Single-nucleotide polymorphisms: a perspective of cardiovascular prevention
Published in
Revista da Associação Médica Brasileira, October 2015
DOI 10.1590/1806-9282.61.05.458
Pubmed ID
Authors

Guilherme Brasil Grezzana, José Luiz da Costa Vieira, Vera Lúcia Portal

Abstract

several studies have evaluated the utilization of lipid biomarkers in an attempt to correlate them with clinical cardiovascular events. Nevertheless, the investigation of clinical conditions under specific plasmatic levels of lipoproteins for long periods presents limitations due to inherent difficulties that are related to the follow-up of individuals throughout their lives. Better understanding of the clinical response and occasional resistance to the action of hypolipidemic drugs in several clinic scenarios is also necessary. to determine the role of evaluation of single-nucleotide polymorphisms (SNPs) related to the metabolism of lipids, and its implications in different clinical scenarios. a search of the literature in English and Spanish languages was performed in Medline, Lilacs via Bireme, IBECS via Bireme, and Cochrane databases. The expected results included information regarding plasmatic lipid profile and SNPs, cardiovascular clinical outcomes and polymorphisms related to the effectiveness of statins in the treatment of hypercholesterolemia. in order to perform this analysis, 19 studies were included from a total of 89 identified citations. The evaluation of the results suggests that low plasmatic levels of LDL-c are associated with a reduction in the risk of heart attacks, although this was not observed for the rise of plasmatic levels of HDL-c. polymorphisms in different populations and clinical perspectives may bring important contributions for a better understanding and adequacy of plasmatic lipoproteins aiming at reducing cardiovascular risk.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 19 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 4 21%
Student > Master 4 21%
Student > Postgraduate 3 16%
Researcher 2 11%
Student > Ph. D. Student 2 11%
Other 3 16%
Unknown 1 5%
Readers by discipline Count As %
Medicine and Dentistry 7 37%
Biochemistry, Genetics and Molecular Biology 5 26%
Nursing and Health Professions 2 11%
Pharmacology, Toxicology and Pharmaceutical Science 1 5%
Business, Management and Accounting 1 5%
Other 2 11%
Unknown 1 5%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 December 2015.
All research outputs
#17,283,763
of 25,371,288 outputs
Outputs from Revista da Associação Médica Brasileira
#404
of 1,105 outputs
Outputs of similar age
#171,587
of 286,859 outputs
Outputs of similar age from Revista da Associação Médica Brasileira
#1
of 4 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,105 research outputs from this source. They receive a mean Attention Score of 2.7. This one is in the 45th percentile – i.e., 45% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 286,859 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them