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Association of Interleukin-17 polymorphism (-197G/A) in chronic and localized aggressive periodontitis

Overview of attention for article published in Brazilian Oral Research, February 2016
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Title
Association of Interleukin-17 polymorphism (-197G/A) in chronic and localized aggressive periodontitis
Published in
Brazilian Oral Research, February 2016
DOI 10.1590/1807-3107bor-2016.vol30.0026
Pubmed ID
Authors

Harshal Liladhar Chaudhari, Shivaraj Warad, Nipun Ashok, Kusai Baroudi, Bassel Tarakji

Abstract

Interleukin 17(IL-17) is a pro-inflammatory cytokine produced mainly by Th17 cells. The present study was undertaken to investigate a possible association between IL-17 A genetic polymorphism at (-197A/G) and susceptibility to chronic and localized aggressive periodontitis (LAgP) in an Indian population. The study was carried out on 105 subjects, which included 35 LAgP patients, 35 chronic periodontitis patients and 35 healthy controls. Blood samples were drawn from the subjects and analyzed for IL-17 genetic polymorphism at (-197A/G), by using the polymerase chain reaction-restriction fragment length polymorphism method. A statistically significant difference was seen in the genotype distribution among chronic periodontitis patients, LAgP patients and healthy subjects. There was a significant difference in the distribution of alleles among chronic periodontitis patients, LAgP patients and healthy subjects. The odds ratio for A allele versus G allele was 5.1 between chronic periodontitis patients and healthy controls, and 5.1 between LAgp patients and healthy controls. Our study concluded that IL-17 A gene polymorphism at (-197A/G) is linked to chronic periodontitis and LAgP in Indian population. The presence of allele A in the IL-17 gene polymorphism (-197A/G) can be considered a risk factor for chronic periodontitis and LAgP.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 45 100%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 10 22%
Student > Ph. D. Student 6 13%
Student > Master 5 11%
Researcher 5 11%
Student > Doctoral Student 4 9%
Other 8 18%
Unknown 7 16%
Readers by discipline Count As %
Medicine and Dentistry 23 51%
Biochemistry, Genetics and Molecular Biology 5 11%
Engineering 3 7%
Agricultural and Biological Sciences 3 7%
Pharmacology, Toxicology and Pharmaceutical Science 1 2%
Other 2 4%
Unknown 8 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 February 2016.
All research outputs
#22,758,309
of 25,371,288 outputs
Outputs from Brazilian Oral Research
#384
of 509 outputs
Outputs of similar age
#269,522
of 313,045 outputs
Outputs of similar age from Brazilian Oral Research
#10
of 28 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 509 research outputs from this source. They receive a mean Attention Score of 2.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 28 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.