ASPECTOS CLÍNICOS, EPIDEMIOLÓGICOS E SOBREVIDA DE CRIANÇAS COM NEUROBLASTOMA: 21 ANOS DE EXPERIÊNCIA DO INSTITUTO DE ONCOLOGIA PEDIÁTRICA, SÃO PAULO

Januária Nunes Lucena, Maria Teresa Seixas Alves, Simone Campos Vieira Abib, Gabriel Oliveira de Souza, Regina Pukenis de Castro Neves, Eliana Maria Monteiro Caran

To describe the clinical and epidemiological characteristics and survival outcomes of children with neuroblastoma (NB) treated at a pediatric oncology center from 1991 to 2012. A retrospective study with clinical and epidemiological data from 258 patients with neuroblastoma treated at a pediatric oncology center from 1991 to 2012, using medical records. The average age of the children at diagnosis was 40.5±46.4 months with a median age of 28.9 months (interquartile range 42.2). The male:female ratio was 1.3:1, and 1% of the patients were asymptomatic. The most frequent manifestations were: fever (25%), abdominal pain (22%), abdominal mass (19%), and bone pain (19%). The mean time from symptom onset to diagnosis was 3.0±4.8 months. The most common location of the tumor was the abdomen (63%). Metastases occurred in the bone marrow (37%) and in the bone (33%). Overall survival (OS) and event-free survival (EFS) in five years were 62 and 52%, respectively. The main cause of death was the progression of the disease (72%). The clinical features of children with neuroblastoma are variable and mostly nonspecific, which makes clinical recognition difficult and, in general, too late. In children less than 5 years old, with an abdominal mass and/or bone pain, irritability, and a fever from an unknown cause, neuroblastoma should be considered as a possible diagnosis.