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Serum Fluorescent Advanced Glycation End (F-AGE) products in gestational diabetes patients

Overview of attention for article published in Archives of Endocrinology and Metabolism, February 2017
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Title
Serum Fluorescent Advanced Glycation End (F-AGE) products in gestational diabetes patients
Published in
Archives of Endocrinology and Metabolism, February 2017
DOI 10.1590/2359-3997000000238
Pubmed ID
Authors

João Paulo Lobo, Catiane Pompilio Brescansin, Izabella C. R. Santos-Weiss, Marciane Welter, Emanuel Maltempi de Souza, Fabiane Gomes de Moraes Rego, Geraldo Picheth, Dayane Alberton

Abstract

Advanced glycation end products (AGEs) are involved in the pathogenesis and complications of diabetes mellitus (DM). Gestational DM (GDM) is characterized by increased glycemia and oxidative stress, which are factors associated with high serum AGE concentrations. The aim of this study was to evaluate the utility of a serum fluorescence AGE (F-AGE) method as a screening tool for gestational diabetes. Serum samples from 225 GDM patients and 217 healthy pregnant women (healthy controls) were diluted 50-fold in phosphate-buffered saline, and the AGEs were estimated by fluorometric analysis (λEx 350 nm/ λEm 440 nm). No significant (P > 0.05) differences in AGE concentrations, expressed in Arbitrary Units (UA/mL × 104), were observed in the women with GDM or in the healthy controls. Furthermore, F-AGE concentrations did not change significantly during the pregnancy (12-32 weeks of gestation). Only the GDM group had a positive correlation (r = 0.421; P < 0.001) between F-AGEs and serum creatinine concentrations. It was not possible to distinguish women with gestational diabetes from the healthy controls on the basis of serum F-AGE concentrations.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 38 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 6 16%
Researcher 6 16%
Student > Master 5 13%
Student > Doctoral Student 3 8%
Other 2 5%
Other 5 13%
Unknown 11 29%
Readers by discipline Count As %
Agricultural and Biological Sciences 7 18%
Medicine and Dentistry 4 11%
Nursing and Health Professions 4 11%
Immunology and Microbiology 2 5%
Biochemistry, Genetics and Molecular Biology 2 5%
Other 3 8%
Unknown 16 42%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 February 2017.
All research outputs
#22,764,772
of 25,382,440 outputs
Outputs from Archives of Endocrinology and Metabolism
#649
of 800 outputs
Outputs of similar age
#371,684
of 431,921 outputs
Outputs of similar age from Archives of Endocrinology and Metabolism
#6
of 7 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 800 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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