Title |
Antimutagenic and antirecombinagenic activities of noni fruit juice in somatic cells of Drosophila melanogaster
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Published in |
Anais da Academia Brasileira de Ciências, June 2013
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DOI | 10.1590/s0001-37652013000200008 |
Pubmed ID | |
Authors |
LEONARDO P. FRANCHI, NILZA N. GUIMARÃES, LAISE R. DE ANDRADE, HELOÍSA H.R. DE ANDRADE, MAURÍCIO LEHMANN, RAFAEL R. DIHL, KÊNYA S. CUNHA |
Abstract |
Noni, a Hawaiian name for the fruit of Morinda citrifolia L., is a traditional medicinal plant from Polynesia widely used for the treatment of many diseases including arthritis, diabetes, asthma, hypertension and cancer. Here, a commercial noni juice (TNJ) was evaluated for its protective activities against the lesions induced by mitomycin C (MMC) and doxorrubicin (DXR) using the Somatic Mutation and Recombination Test (SMART) in Drosophila melanogaster. Three-day-old larvae, trans-heterozygous for two genetic markers (mwh and flr3 ), were co-treated with TNJ plus MMC or DXR. We have observed a reduction in genotoxic effects of MMC and DXR caused by the juice. TNJ provoked a marked decrease in all kinds of MMC- and DXR-induced mutant spots, mainly due to its antirecombinagenic activity. The TNJ protective effects were concentration-dependent, indicating a dose-response correlation, that can be attributed to a powerful antioxidant and/or free radical scavenger ability of TNJ. |
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