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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Leptin: molecular mechanisms, systemic pro-inflammatory effects, and clinical implications
|
|---|---|
| Published in |
Archives of Endocrinology and Metabolism, January 2013
|
| DOI | 10.1590/s0004-27302012000900001 |
| Pubmed ID | |
| Authors |
Gilberto Paz-Filho, Claudio Mastronardi, Carina Bertoldi Franco, Kevin Boyang Wang, Ma-Li Wong, Julio Licinio |
| Abstract |
Leptin, the adipokine produced mainly by the white adipose tissue, plays important roles not only in the regulation of food intake, but also in controlling immunity and inflammation. It has been widely demonstrated that the absence of leptin leads to immune defects in animal and human models, ultimately increasing mortality. Leptin also regulates inflammation by means of actions on its receptor, that is widely spread across different immune cell populations. The molecular mechanisms by which leptin determines its biological actions have also been recently elucidated, and three intracellular pathways have been implicated in leptin actions: JAK-STAT, PI3K, and ERK 1/2. These pathways are closely regulated by intracellular proteins that decrease leptin biological activity. In this review, we discuss the molecular mechanisms by which leptin regulates immunity and inflammation, and associate those mechanisms with chronic inflammatory disorders. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 50% |
| United States | 1 | 25% |
| Australia | 1 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 75% |
| Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 107 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 107 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 2 | 2% |
| Researcher | 1 | <1% |
| Lecturer > Senior Lecturer | 1 | <1% |
| Student > Master | 1 | <1% |
| Unknown | 102 | 95% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 1 | <1% |
| Nursing and Health Professions | 1 | <1% |
| Immunology and Microbiology | 1 | <1% |
| Medicine and Dentistry | 1 | <1% |
| Engineering | 1 | <1% |
| Other | 0 | 0% |
| Unknown | 102 | 95% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 June 2019.
All research outputs
#6,496,331
of 25,374,917 outputs
Outputs from Archives of Endocrinology and Metabolism
#106
of 800 outputs
Outputs of similar age
#67,388
of 307,813 outputs
Outputs of similar age from Archives of Endocrinology and Metabolism
#2
of 25 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 800 research outputs from this source. They receive a mean Attention Score of 3.3. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 307,813 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 77% of its contemporaries.
We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.