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Mendeley readers
| Title |
The value of csf analysis for the differential diagnosis of HTLV-I associated myelopathy and multiple sclerosis
|
|---|---|
| Published in |
Arquivos de Neuro-Psiquiatria, December 2010
|
| DOI | 10.1590/s0004-282x1995000500008 |
| Pubmed ID | |
| Authors |
Marzia Puccioni-Sohler, Bernd Kitze, Klaus Felgenhauer, Iris T. Graef, Peter Lange, Sergio Novis, Hansotto Reiber, Beatriz Vaz |
| Abstract |
Cerebrospinal fluid (CSF) and serum of 17 patients with HAM/TSP (HTLV-I associated myelopathy/tropical spastic paraparesis), six with multiple sclerosis and six with idiopathic epilepsy (non inflammatory control) from Brazil were analysed for the presence of intrathecal synthesis of virus-specific antibodies against measles, rubella, varicella zoster virus and herpes simplex virus by enzyme-linked immunosorbent assay (ELISA). All HAM/TSP and multiple sclerosis cases had an intrathecal immune response (oligoclonal IgG). In HAM/TSP, only 1/17 case showed a polyspecific intrathecal immune response against measles and rubella virus. In multiple sclerosis, specific antibodies against measles and rubella (MRZ response) were observed in all patients but not in the control with idiopathic epilepsy. The diagnostic and theoretical relevance of mono- and polyspecific immune responses is discussed for these chronic neurological diseases. |
Mendeley readers
The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | 5% |
| Unknown | 18 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 2 | 11% |
| Researcher | 2 | 11% |
| Student > Bachelor | 2 | 11% |
| Student > Postgraduate | 2 | 11% |
| Professor > Associate Professor | 2 | 11% |
| Other | 5 | 26% |
| Unknown | 4 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 10 | 53% |
| Neuroscience | 3 | 16% |
| Agricultural and Biological Sciences | 1 | 5% |
| Social Sciences | 1 | 5% |
| Unknown | 4 | 21% |