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Neurogenesis induced by seizures in the dentate gyrus is not related to mossy fiber sprouting but is age dependent in developing rats

Overview of attention for article published in Arquivos de Neuro-Psiquiatria, December 2008
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Title
Neurogenesis induced by seizures in the dentate gyrus is not related to mossy fiber sprouting but is age dependent in developing rats
Published in
Arquivos de Neuro-Psiquiatria, December 2008
DOI 10.1590/s0004-282x2008000600015
Pubmed ID
Authors

Yaima del Carmen Garrido Sanabria, Gustavo Adolfo Argañaraz, Eliangela Lima, Margareth Rose Priel, Edvaldo da Silva Trindade, Luana Mazzacoratti Loeb, Fulvio Alexandre Scorza, Esper Abrão Cavalheiro, Débora Amado, Maria da Graça Naffah-Mazzacoratti

Abstract

Neurogenesis in the dentate gyrus (DG) has attracted attention since abnormal supragranular mossy fiber sprouting occurs in the same region, in temporal lobe epilepsy. Thus, we submitted developing rats to pilocarpine-induced status epilepticus (SE) to study the relationship between neurogenesis and mossy fiber sprouting. Groups were submitted to SE at: I-P9, II-P7, P8 and P9, III-P17 e IV-P21. Neurogenesis was quantified using BrdU protocol and confirmed through double staining, using neuronal pentraxin. Other animals were monitored by video system until P120 and their brain was studied (Timm and Nissl staining). The neurogenesis at P17 (p=0.007) and P21 (p=0.006) were increased. However, only P21 group showed recurrent seizures and the mossy fiber sprouting in the same region, during adult life, while P17 did not. Thus, our results suggest that neurogenesis is not related to mossy fiber sprouting neither to recurrent spontaneous seizures in pilocarpine model.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 4%
Unknown 25 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 15%
Researcher 3 12%
Student > Doctoral Student 3 12%
Student > Bachelor 3 12%
Professor > Associate Professor 3 12%
Other 7 27%
Unknown 3 12%
Readers by discipline Count As %
Neuroscience 7 27%
Agricultural and Biological Sciences 6 23%
Medicine and Dentistry 4 15%
Environmental Science 2 8%
Psychology 1 4%
Other 2 8%
Unknown 4 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 January 2009.
All research outputs
#17,286,379
of 25,374,647 outputs
Outputs from Arquivos de Neuro-Psiquiatria
#757
of 1,369 outputs
Outputs of similar age
#152,248
of 179,148 outputs
Outputs of similar age from Arquivos de Neuro-Psiquiatria
#8
of 10 outputs
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So far Altmetric has tracked 1,369 research outputs from this source. They receive a mean Attention Score of 4.0. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
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