Title |
Prognostic factors predicting a fatal outcome in HIV-negative children with neurotuberculosis
|
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Published in |
Arquivos de Neuro-Psiquiatria, October 2010
|
DOI | 10.1590/s0004-282x2010000500015 |
Pubmed ID | |
Authors |
Murilo Gimenes Rodrigues, Jaime Lin, Marcelo Rodrigues Masruha, Luiz Celso Pereira Vilanova, Thais Soares Cianciarullo Minett |
Abstract |
To identify prognostic factors predicting a fatal outcome in HIV-negative children with neurotuberculosis based on clinical, epidemiological, and laboratory findings. The clinical records of all in-patients diagnosed with neurotuberculosis from 1982 to 2005 were evaluated retrospectively. The following prognostic parameters were examined: gender, age, close contact with a tuberculosis-infected individual, vaccination for bacillus Calmette-Guérin, purified protein derivative (PPD) of tuberculin results, concomitant miliary tuberculosis, seizures, CSF results, and hydrocephalus. One hundred forty-one patients diagnosed with neurotuberculosis were included. Seventeen percent of the cases resulted in death. The factors that were correlated with a negative outcome included lack of contact with a tuberculosis-infected individual, negative PPD reaction, coma, and longer hospitalisation time. A multiple logistic regression analysis was performed to identify which of these factors most often resulted in death. Coma at diagnosis, lack of tuberculosis contact, and a non-reactive PPD were the most important predictors of fatality in patients with neurotuberculosis. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | 2% |
Unknown | 51 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 14 | 27% |
Student > Doctoral Student | 7 | 13% |
Student > Master | 7 | 13% |
Researcher | 5 | 10% |
Student > Ph. D. Student | 5 | 10% |
Other | 8 | 15% |
Unknown | 6 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 23 | 44% |
Nursing and Health Professions | 7 | 13% |
Biochemistry, Genetics and Molecular Biology | 4 | 8% |
Agricultural and Biological Sciences | 2 | 4% |
Immunology and Microbiology | 2 | 4% |
Other | 5 | 10% |
Unknown | 9 | 17% |