Title |
The hamster cheek pouch: an immunologically privileged site suitable to the study of granulomatous infections
|
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Published in |
Revista do Instituto de Medicina Tropical de Sao Paulo, September 2006
|
DOI | 10.1590/s0036-46651995000400004 |
Pubmed ID | |
Authors |
M. S. P. de Arruda, M. R. Montenegro |
Abstract |
The hamster cheek pouch is an invagination of oral mucosa, characterized histologically as skin-like. In this paper we describe anatomical, histological and embriological features of the pouch and comment on the pouch as an immunologically privileged site since it lacks lymphatic drainage and has few Langerhans cells. We present the review from literature and our observations after inoculation in the pouch of mycobacteriae (BCG, Mycobacterium tuberculosis and Mycobacterium leprae) and a fungus (Paracoccidioides brasiliensis). Lesions in the pouch were granulomatous but smaller and long lasting; even granulomatous, the reaction was inefficient to control the proliferation of agents compared with inoculation in other sites, except for BCG. Appearance of immunity was also delayed or absent and, when it was detected, a sharp decrease in number of agents in pouch lesions was observed. These observations make the pouch an interesting site for the study of the role of immune system in infectious diseases and in granuloma formation. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 15 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 3 | 20% |
Other | 2 | 13% |
Professor | 2 | 13% |
Student > Master | 2 | 13% |
Researcher | 2 | 13% |
Other | 2 | 13% |
Unknown | 2 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Veterinary Science and Veterinary Medicine | 2 | 13% |
Medicine and Dentistry | 2 | 13% |
Agricultural and Biological Sciences | 2 | 13% |
Biochemistry, Genetics and Molecular Biology | 1 | 7% |
Nursing and Health Professions | 1 | 7% |
Other | 2 | 13% |
Unknown | 5 | 33% |