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Phialemonium curvatum infection after bone marrow transplantation

Overview of attention for article published in Revista do Instituto de Medicina Tropical de Sao Paulo, July 2001
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Title
Phialemonium curvatum infection after bone marrow transplantation
Published in
Revista do Instituto de Medicina Tropical de Sao Paulo, July 2001
DOI 10.1590/s0036-46652001000300009
Pubmed ID
Authors

Elisabeth Maria HEINS-VACCARI, Clarisse M. MACHADO, Rosaura S. SABOYA, Roberto L. SILVA, Frederico L. DULLEY, Carlos da S. LACAZ, Roseli S. de FREITAS LEITE, Giovana L. HERNANDEZ ARRIAGADA

Abstract

We report a case of cutaneous infection caused by Phialemonium curvatum GAMS et COOKE, 1983, after bone marrow transplantation. The genus Phialemonium was created by GAMS & MCGINNIS in 1983 including three new species: Ph. obovatum, Ph. curvatum and Ph. dimorphosporum, and represents an intermediate genus between Acremonium and Phialophora. Nowadays, the genus Phialemonium is considered to be a pheoid fungus which may cause the eventual lesions observed in pheo- and hyalohyphomycosis. Species of this genus have been described as opportunistic agents in humans and animals, mainly as a result of immunosuppression. In the present case, the patient had multiple myeloma and received an allogenic bone marrow transplant from his HLA-compatible brother. Two months after transplantation, he developed purplish and painful nodular lesions on the right ankle. Some of these lesions drained spontaneously and apparently hyaline mycelial filaments were observed, whose culture was initially identified as Acremonium sp. Subsequent studies showed that the fungus was Phialemonium curvatum. The infection was treated with amphotericin B, followed by ketoconazole. The patient was submitted to surgical debridement followed by two skin grafts to repair the bloody area. The duration of the treatment was 4 months and secondary prophylaxis with ketoconazole alone was maintained for one additional month. No recurrence was observed after discontinuation of treatment. The authors comment on the pathogenicity of the genus Phialemonium.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 5%
Unknown 20 95%

Demographic breakdown

Readers by professional status Count As %
Other 5 24%
Student > Bachelor 5 24%
Student > Master 2 10%
Professor > Associate Professor 2 10%
Researcher 2 10%
Other 2 10%
Unknown 3 14%
Readers by discipline Count As %
Medicine and Dentistry 7 33%
Agricultural and Biological Sciences 3 14%
Unspecified 1 5%
Biochemistry, Genetics and Molecular Biology 1 5%
Chemical Engineering 1 5%
Other 4 19%
Unknown 4 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 December 2013.
All research outputs
#8,535,472
of 25,374,647 outputs
Outputs from Revista do Instituto de Medicina Tropical de Sao Paulo
#133
of 785 outputs
Outputs of similar age
#13,988
of 40,900 outputs
Outputs of similar age from Revista do Instituto de Medicina Tropical de Sao Paulo
#2
of 4 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 785 research outputs from this source. They receive a mean Attention Score of 3.3. This one has gotten more attention than average, scoring higher than 58% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 40,900 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 10th percentile – i.e., 10% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.