Title |
HTLV-1/2 seroprevalence and coinfection rate in Brazilian first-time blood donors: an 11-year follow-up
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Published in |
Revista do Instituto de Medicina Tropical de Sao Paulo, June 2012
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DOI | 10.1590/s0036-46652012000300002 |
Pubmed ID | |
Authors |
Mariana Tomazini Pinto, Evandra Strazza Rodrigues, Tathiane Maistro Malta, Rochele Azevedo, Osvaldo Massaiti Takayanagui, Vanderléia Bárbaro Valente, Eugênia Maria Amorim Ubiali, Dimas Tadeu Covas, Simone Kashima |
Abstract |
The seroprevalence and geographic distribution of HTLV-1/2 among blood donors are extremely important to transfusion services. We evaluated the seroprevalence of HTLV-1/2 infection among first-time blood donor candidates in Ribeirão Preto city and region. From January 2000 to December 2010, 1,038,489 blood donations were obtained and 301,470 were first-time blood donations. All samples were screened with serological tests for HTLV-1/2 using enzyme immunoassay (EIA). In addition, the frequency of coinfection with hepatitis B virus (HBV), hepatitis C virus (HCV), human immunodeficiency virus (HIV), Chagas disease (CD) and syphilis was also determined. In-house PCR was used as confirmatory test for HTLV-1/2. A total of 296 (0.1%) first-time donors were serologically reactive for HTLV-1/2. Confirmatory PCR of 63 samples showed that 28 were HTLV-1 positive, 13 HTLV-2 positive, 19 negative and three indeterminate. Regarding HTLV coinfection rates, the most prevalent was with HBV (51.3%) and HCV (35.9%), but coinfection with HIV, CD and syphilis was also detected. The real number of HTLV-infected individual and coinfection rate in the population is underestimated and epidemiological studies like ours are very informative. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Russia | 1 | 4% |
Brazil | 1 | 4% |
Unknown | 25 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 5 | 19% |
Student > Doctoral Student | 4 | 15% |
Student > Ph. D. Student | 4 | 15% |
Student > Master | 4 | 15% |
Researcher | 2 | 7% |
Other | 4 | 15% |
Unknown | 4 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 7 | 26% |
Biochemistry, Genetics and Molecular Biology | 5 | 19% |
Agricultural and Biological Sciences | 5 | 19% |
Nursing and Health Professions | 3 | 11% |
Environmental Science | 2 | 7% |
Other | 1 | 4% |
Unknown | 4 | 15% |