Title |
Comparison of five methods for oxacillin susceptibility testing of Staphylococcus aureus isolates from cystic fibrosis patients
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Published in |
Revista do Instituto de Medicina Tropical de Sao Paulo, December 2012
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DOI | 10.1590/s0036-46652012000600002 |
Pubmed ID | |
Authors |
Marcelo J. Mimica, Rozane L. Carvalho, Eitan N. Berezin, Neiva Damaceno, Hélio H. Caiaffa-Filho |
Abstract |
Methicillin-resistant Staphylococcus aureus (MRSA) are now a worldwide problem. Cystic fibrosis (CF) patients are commonly colonized and infected by MRSA. Accurate oxacillin susceptibility testing is mandatory for the adequate management of these patients. We performed a comparison of the accuracy of different tests in CF isolates, including methicillin-susceptible S. aureus and MRSA with different SCCmec types, and using the mecA gene as the gold-standard. The sensitivity and specificity of oxacillin disc, Etest, and oxacillin agar screening plate were 100%. Sensitivity of the cefoxitin disc was 85% and specificity was 100%. For clinically relevant isolates, laboratories may consider the use of a combination of two phenotypic methods. |
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Geographical breakdown
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United States | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |