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Attention Score in Context
| Title |
Effects of vitamin C supplementation on acute phase Chagas disease in experimentally infected mice with Trypanosoma cruzi QM1 strain
|
|---|---|
| Published in |
Revista do Instituto de Medicina Tropical de Sao Paulo, December 2012
|
| DOI | 10.1590/s0036-46652012000600006 |
| Pubmed ID | |
| Authors |
Ricardo Guimarães Marim, Alex Silva de Gusmão, Roberto Esteves Pires Castanho, Rafael Deminice, Altino Luiz Silva Therezo, Alceu Afonso Jordão Júnior, Luciamare Perinetti Alves Martins |
| Abstract |
The tissue changes that occur in Chagas disease are related to the degree of oxidative stress and antioxidant capacity of affected tissue. Studies with vitamin C supplementation did not develop oxidative damage caused by Chagas disease in the host, but other studies cite the use of peroxiredoxins ascorbate - dependent on T. cruzi to offer protection against immune reaction. Based on these propositions, thirty "Swiss" mice were infected with T. cruzi QM1 strain and treated with two different vitamin C doses in order to study the parasitemia evolution, histopathological changes and lipid peroxidation biomarkers during the acute phase of Chagas disease. The results showed that the parasite clearance was greater in animals fed with vitamin C overdose. There were no significant differences regarding the biomarkers of lipid peroxidation and inflammatory process or the increase of myocardium in animals treated with the recommended dosage. The largest amount of parasite growth towards the end of the acute phase suggests the benefit of high doses of vitamin C for trypomastigotes. The supplementation doesn't influence the production of free radicals or the number of amastigote nests in the acute phase of Chagas disease. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 18 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Doctoral Student | 2 | 11% |
| Student > Master | 2 | 11% |
| Lecturer | 1 | 6% |
| Student > Ph. D. Student | 1 | 6% |
| Other | 1 | 6% |
| Other | 0 | 0% |
| Unknown | 11 | 61% |
| Readers by discipline | Count | As % |
|---|---|---|
| Computer Science | 6 | 33% |
| Biochemistry, Genetics and Molecular Biology | 2 | 11% |
| Unknown | 10 | 56% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 November 2019.
All research outputs
#7,968,106
of 25,394,764 outputs
Outputs from Revista do Instituto de Medicina Tropical de Sao Paulo
#110
of 785 outputs
Outputs of similar age
#78,099
of 285,886 outputs
Outputs of similar age from Revista do Instituto de Medicina Tropical de Sao Paulo
#1
of 22 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 785 research outputs from this source. They receive a mean Attention Score of 3.3. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 285,886 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.