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Antiretroviral activity of protease inhibitors against Toxoplasma gondii

Overview of attention for article published in Revista do Instituto de Medicina Tropical de Sao Paulo, February 2013
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Title
Antiretroviral activity of protease inhibitors against Toxoplasma gondii
Published in
Revista do Instituto de Medicina Tropical de Sao Paulo, February 2013
DOI 10.1590/s0036-46652013000100012
Pubmed ID
Authors

Lianet Monzote, Marta Rodríguez, Yenisey Alfonso, Raymundo Cox

Abstract

The introduction of highly active antiretroviral therapy (HAART) has caused a marked reduction in the occurrence and severity of parasitic infections, including the toxoplasmic encephalitis (TE). These changes have been attributed to the restoration of cell-mediated immunity. This study was developed to examine the activity of six antiretroviral protease inhibitors (API) on Toxoplasma gondii tachyzoites. The six API showed anti-Toxoplasma activity, with IC50 value between 1.4 and 6.6 µg/mL. Further studies at the molecular level should be performed to clarify if the use of API could be beneficial or not for AIDS patients with TE.

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Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 January 2013.
All research outputs
#19,944,091
of 25,373,627 outputs
Outputs from Revista do Instituto de Medicina Tropical de Sao Paulo
#529
of 785 outputs
Outputs of similar age
#221,855
of 291,207 outputs
Outputs of similar age from Revista do Instituto de Medicina Tropical de Sao Paulo
#7
of 15 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 785 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 291,207 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.