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SERUM LEVELS OF COPPER AND IRON IN DENGUE FEVER

Overview of attention for article published in Revista do Instituto de Medicina Tropical de Sao Paulo, January 2015
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Title
SERUM LEVELS OF COPPER AND IRON IN DENGUE FEVER
Published in
Revista do Instituto de Medicina Tropical de Sao Paulo, January 2015
DOI 10.1590/s0036-46652015000400007
Pubmed ID
Authors

Rajendiran Soundravally, Jacob Sherin, Balakrishna Pillai Agieshkumar, Mariya Samadanam Daisy, Cherupanakkal Cleetus, Parameswaran Narayanan, Tamilarasu Kadhiravan, Sistla Sujatha, Kottyen Thazhath Harichandrakumar

Abstract

SUMMARYThe role of trace elements in dengue virulence is not yet known. The present study assessed the serum levels of two micronutrients, copper and iron, in cases of dengue fever. The study involved 96 patients of whom 48 had either severe or non-severe forms of dengue (with and without warning signs), and the remaining 48 were patients with other febrile illnesses (OFI), used as controls. Serum levels of copper and iron were evaluated at admission and by the time of defervescence using commercially available kits. At admission, no difference in the level of serum copper was observed between cases and controls. In the group of dengue cases, the copper level was found to be significantly decreased in severe and non-severe cases with warning signs, compared to non-severe cases without warning signs. In contrast, by the time of defervescence the copper level was found to be increased in all dengue cases compared to OFI controls, but no difference was observed among dengue cases. Unlike OFI controls, dengue cases showed an increasing pattern of copper levels from admission until defervescence. On the other hand, no such significant differences were observed in the serum level of iron in the clinical groups, except for a decreased iron level found in severe cases, compared to non-severe dengue without warning signs. The results show that copper is associated with dengue severity and this finding emphasizes the need to investigate the involvement of trace elements in disease severity so as to improve the prognosis of dengue.

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Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 May 2023.
All research outputs
#16,188,873
of 25,584,565 outputs
Outputs from Revista do Instituto de Medicina Tropical de Sao Paulo
#393
of 788 outputs
Outputs of similar age
#200,317
of 360,666 outputs
Outputs of similar age from Revista do Instituto de Medicina Tropical de Sao Paulo
#15
of 63 outputs
Altmetric has tracked 25,584,565 research outputs across all sources so far. This one is in the 34th percentile – i.e., 34% of other outputs scored the same or lower than it.
So far Altmetric has tracked 788 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 360,666 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 63 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.