Title |
Genes and Chromosomes of Leishmania infantum
|
---|---|
Published in |
Memórias do Instituto Oswaldo Cruz, October 1998
|
DOI | 10.1590/s0074-02761997000600022 |
Pubmed ID | |
Authors |
Jose María Requena, Manuel Soto, Luis Quijada, Carlos Alonso |
Abstract |
During recent years, several Leishmania infantum genes have been cloned and characterized. Here, we have summarized the available information on the gene organization and expression in this protozoan parasite. From a comparative analysis, the following outstanding features were found to be common to most of the genes characterized: tandemly organized genes with conserved coding regions and divergent untranslated regions, polycistronic transcription and post-transcriptional regulation of gene expression. The analysis of chromosomes of L. infantum by pulsed-field electrophoresis showed the existence of both size and number polymorphisms such that each strain has a distinctive molecular karyotype. Despite this variability, highly conserved physical linkage groups exists among different strains of L. infantum and even among Old World Leishmania species. Gene mapping on the L. infantum molecular karyotype evidenced a bias in chromosomal distribution of, at least, the evolutionary conserved genes. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 1 | 3% |
Unknown | 29 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 7 | 23% |
Professor > Associate Professor | 4 | 13% |
Student > Master | 4 | 13% |
Student > Bachelor | 2 | 7% |
Professor | 2 | 7% |
Other | 7 | 23% |
Unknown | 4 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 10 | 33% |
Biochemistry, Genetics and Molecular Biology | 8 | 27% |
Medicine and Dentistry | 3 | 10% |
Chemistry | 2 | 7% |
Environmental Science | 1 | 3% |
Other | 1 | 3% |
Unknown | 5 | 17% |